Pennsylvania Route 320 is a north–south state highway in southeastern Pennsylvania. The southern terminus of the 18.8-mile (30.3 km) long route is at U.S. Route 13 /PA 291 in Chester. The northern terminus is at PA 23 in Swedeland. The route passes through suburban areas in Delaware and Montgomery counties to the west of Philadelphia, serving Swarthmore, Springfield, Broomall, Villanova, and Gulph Mills. PA 320 intersects many important highways including US 13 Business and Interstate 95 (I-95) in Chester, US 1 in Springfield, US 30 in Villanova, and I-76 in Gulph Mills. PA 320 runs parallel to I-476 for much of its length and crosses it four times. Even though there are no direct interchanges between I-476 and PA 320, several roads that intersect PA 320 provide access to I-476.

U.S. Route 13 (US 13) is a United States Numbered Highway running from Fayetteville, North Carolina, north to Morrisville, Pennsylvania. The route runs for 49.359 miles (79.436 km) through the Delaware Valley in the U.S. state of Pennsylvania. The route enters the state from Delaware in Marcus Hook, Delaware County. It continues northeast through Delaware County, passing through the city of Chester before heading through suburban areas along Chester Pike to Darby. US 13 enters the city of Philadelphia on Baltimore Avenue and runs through West Philadelphia to University City, where it turns north along several city streets before heading east across the Schuylkill River along Girard Avenue. The route turns north and heads to North Philadelphia, where it runs northeast along Hunting Park Avenue. US 13 becomes concurrent with US 1 on Roosevelt Boulevard, continuing into Northeast Philadelphia. US 13 splits southeast on a one-way pair of streets before heading northeast out of the city on Frankford Avenue. The route continues into Bucks County as Bristol Pike, heading northeast to Bristol, where it turns into a divided highway. US 13 becomes a freeway in Tullytown and continues north to its terminus at US 1 in Falls Township, near Morrisville. US 13 roughly parallels Interstate 95 (I-95) through its course in Pennsylvania.