Pennsylvania Route 325 is a 30-mile-long (48 km) state highway located in Dauphin and Schuylkill counties in Pennsylvania. The western terminus is at the intersection of Mountain Road and Earl Drive, just past an interchange with U.S. Route 22 /US 322, in the community of Speeceville in Middle Paxton Township. The eastern terminus is at US 209 in Tower City. PA 325 runs through a narrow valley for its length, passing through forested areas with some farmland. The route forms a concurrency with PA 225 to the north of Dauphin. The road was paved in stages between 1930 and the 1940s. PA 325 was designated in the 1940s to run between US 22/US 322/PA 14 in Speeceville east to US 209 in Tower City. In 1999, an interchange with US 22/US 322 was constructed near the western terminus; the end of PA 325 remained at Riverview Road, the former alignment of US 22/US 322.

Pennsylvania Route 326 is a 24-mile-long (39 km) state highway located in Bedford County, Pennsylvania. The southern terminus is at the Maryland state line near Flintstone, Maryland. The northern terminus is at U.S. Route 30 east of Bedford.