Pennsylvania Route 372 is an east–west highway in York, Lancaster, and Chester counties in the U.S. state of Pennsylvania. Its western terminus is at PA 74 in Lower Chanceford Township north of Delta and west of Holtwood, and its eastern terminus is at PA 82 in Coatesville. PA 372 heads east from PA 74 in York County and crosses the Susquehanna River on the Norman Wood Bridge. The route continues through Lancaster County, intersecting PA 272 in Buck, U.S. Route 222 and PA 472 in Quarryville, and PA 896 in Georgetown. PA 372 crosses into Chester County and intersects PA 41 in Atglen and PA 10 in Parkesburg before continuing to Coatesville. PA 372 is a two-lane undivided road throughout its length.

Chester County, colloquially referred to as Chesco, is a county in the Commonwealth of Pennsylvania. It is located in the Delaware Valley region, located in the southeastern part of the state. As of the 2020 census, the population was 545,823(As of 2022), increasing by 7.1% from 498,886 in 2010. The county seat is the Borough of West Chester. The most populous of its 73 municipalities is Tredyffrin Township. The most populous boroughs are West Chester and Phoenixville. Coatesville is the only municipality in the County organized under the City form of government, a technical rather than demographic distinction. Chester County was one of the three original Pennsylvania counties created by William Penn in 1682. It was named for Chester, England. The county is part of the Southeast Pennsylvania region of the state.