Pennsylvania Route 374 (PA 374) is a 17.7-mile-long (28.5 km) state highway located in Susquehanna County, Pennsylvania. The western terminus is at PA 92 in the community of Glenwood in Lenox Township. The eastern terminus is at PA 171 and PA 371 in the community of Herrick Center near Union Dale in Herrick Township. The route is a two-lane undivided road that passes through rural areas of farms and woods in southern Susquehanna County. PA 374 intersects PA 407 and Interstate 81 (I-81) in Lenox Township and forms a concurrency with PA 106 in Clifford Township.

Susquehanna County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 38,434 Its county seat is Montrose. The county was created on February 21, 1810, from part of Luzerne County and later organized in 1812. It is named for the Susquehanna River. The county is part of the Northeast Pennsylvania region of the state.