Pennsylvania Route 38 is a 40.2-mile-long (64.7 km) state highway located in northwest Pennsylvania. The southern terminus is at U.S. Route 422 and PA 68 northeast of downtown Butler. The northern terminus is at US 322 in Rockland Township.

U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey, meeting the New Jersey Turnpike at exit 2. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.