Pennsylvania Route 407 is a 12.5-mile-long (20.1 km) state highway located in Lackawanna and Susquehanna counties in Pennsylvania. The southern terminus is at U.S. Route 6 /US 11 in South Abington Township, Pennsylvania near Clarks Summit near the northern terminus of Interstate 476 (I-476), also known as the Pennsylvania Turnpike Northeast Extension. The northern terminus is at PA 374 near Glenwood. PA 407 is a two-lane road that serves Clarks Green and Waverly in northern Lackawanna County. This route was part of the Philadelphia and Great Bend Turnpike, a turnpike that was built in 1826. PA 407 was designated in 1928 between US 6/US 11 in Clarks Summit and PA 107 in Fleetville. The route was extended north to PA 374 in 1961. PA 407 was rerouted to its current southern terminus in 2004.

Lackawanna County is a county in the Commonwealth of Pennsylvania. It is located in Northeastern Pennsylvania and had a population of 215,615 (2022). Its county seat and most populous city is Scranton. The county is part of the Northeast Pennsylvania region of the state.