Pennsylvania Route 443 is an 80-mile-long (130 km) east–west state highway in the US state of Pennsylvania. The western terminus is at an intersection with State Route 3009 at North Front Street on the east bank of the Susquehanna River in the community of Fort Hunter in Middle Paxton Township, just west of an interchange with the U.S. Route 22 /US 322 freeway. The eastern terminus is at US 209 in Lehighton. The route runs through rural areas in the Ridge-and-Valley Appalachians in Dauphin, Lebanon, Schuylkill, and Carbon counties, serving Fort Indiantown Gap, Pine Grove, Schuylkill Haven, Orwigsburg, New Ringgold, and South Tamaqua. PA 443 intersects several major roads, including US 22/US 322 near its western terminus, PA 72 in Union Township, Interstate 81 (I-81) near Pine Grove, PA 61 between Schuylkill Haven and Orwigsburg, and PA 309 in South Tamaqua.

U.S. Route 22 (US 22) is an east–west United States Numbered Highway that stretches from Cincinnati, Ohio, in the west, to Newark, New Jersey, in the east. In Pennsylvania, the route runs for 338.20 miles (544.28 km) between the West Virginia state line in Washington County, where it is a freeway through the western suburbs of Pittsburgh, and then runs east to Easton and the Pennsylvania–New Jersey state line in the Lehigh Valley region of eastern Pennsylvania.