Pennsylvania Route 45 is an 86-mile-long (138 km) state highway that is located in central Pennsylvania, United States. The western terminus of the route is situated at PA 453 in Morris Township near the community of Water Street. The eastern terminus is located at PA 642 west of the small town of Mooresburg.

U.S. Route 322 is a spur of US 22, running from Cleveland, Ohio, east to Atlantic City, New Jersey. In the U.S. state of Pennsylvania, the route runs from the Ohio state line in West Shenango Township southeast to the Commodore Barry Bridge over the Delaware River in Chester, at which point the route crosses into New Jersey, meeting the New Jersey Turnpike at exit 2. The route passes near or through several cities, including Meadville, DuBois, State College, and Harrisburg. US 322 in Pennsylvania is named the 28th Division Highway in honor of the 28th Infantry Division.