Pennsylvania Route 472 is a north–south state highway in Chester and Lancaster counties in Pennsylvania. Its southern terminus is at PA 841 in Lewisville 300 yards (270 m) north of the Maryland border. Its northern terminus is at PA 372 in Quarryville. PA 472 is a two-lane undivided road that passes through mostly rural areas along a northwest-southeast alignment. The route passes through the borough of Oxford, where it intersects the southern terminus of PA 10 and has an interchange with U.S. Route 1. PA 472 was originally designated in 1928 between US 1/PA 12/PA 42 in Oxford and PA 372 in Quarryville. The route was extended south to Hickory Hill by 1930, at which time the entire length of the route was paved. The southern terminus of PA 472 was extended to PA 841 in Lewisville in 1937.

U.S. Route 1 (US 1) is a major north–south U.S. Route, extending from Key West, Florida, in the south to Fort Kent, Maine, at the Canada–United States border in the north. In the U.S. state of Pennsylvania, US 1 runs for 81 miles (130 km) from the Maryland state line near Nottingham northeast to the New Jersey state line at the Delaware River in Morrisville, through the southeastern portion of the state. The route runs southwest to northeast and serves as a major arterial road through the city of Philadelphia and for many of the suburbs in the Delaware Valley metropolitan area. South of Philadelphia, the road mostly follows the alignment of the Baltimore Pike. Within Philadelphia, it mostly follows Roosevelt Boulevard. North of Philadelphia, US 1 parallels the route of the Lincoln Highway. Several portions of US 1 in Pennsylvania are freeways, including from near the Maryland state line to Kennett Square, the bypass of Media, the concurrency with Interstate 76 and the Roosevelt Expressway in Philadelphia, and between Bensalem Township and the New Jersey state line.