Pennsylvania Route 72 is a 37.8-mile-long (60.8 km) north–south state route located in southeast Pennsylvania. The southern terminus of the route is at U.S. Route 222 /PA 272 in Lancaster. The northern terminus is at PA 443 north of Lickdale in Union Township. PA 72 serves as a major road connecting Lancaster and Lebanon counties, serving East Petersburg, Manheim, Cornwall, Lebanon, and Jonestown. The route intersects several major roads including US 30 and PA 283 north of Lancaster, the Pennsylvania Turnpike south of Cornwall, US 322 along a concurrency on a freeway bypassing Cornwall, US 422 in Lebanon, US 22 near Jonestown, and I-81 via Fisher Avenue in Lickdale.

U.S. Route 222 is a U.S. Highway that is a spur of US 22 in the states of Maryland and Pennsylvania. It runs for 95 miles (153 km) from US 1 in Conowingo, Maryland, north to the junction of Interstate 78 (I-78) and Pennsylvania Route 309 in Dorneyville, Pennsylvania. US 222 is almost entirely in Pennsylvania, and serves as the state's principal artery between the Lancaster and Reading areas in the west and the Lehigh Valley in the east.