Pennsylvania Route 88 is a 68-mile-long (109 km) north–south state highway located in southwestern Pennsylvania. The southern terminus of the route is at U.S. Route 119 (US 119) in Point Marion less than 2 miles (3 km) from the Pennsylvania-West Virginia border. The northern terminus is at PA 51 in Pittsburgh. PA 88 runs parallel to the Monongahela River for almost its entire length.

U.S. Route 119 (US 119) travels through Connellsville, Greensburg, and Punxsutawney, and bypasses Uniontown and Indiana. There are numerous other boroughs and villages along its 133-mile (214 km) route in the Keystone State. The southern entrance of US 119 is at the West Virginia state line one-half-mile south of Point Marion. The northern terminus is at US 219 two miles (3 km) south of DuBois, Pennsylvania. US 119 is in the National Highway System from the West Virginia state line to Exit 0 of PA Turnpike 66, and from US 22 to US 219. From US 22 to US 219, the highway carries the name of the Buffalo-Pittsburgh Highway; from US 22 to PA 56, it is also known as the Patrick J. Stapleton Highway; near Uniontown, it bears the name George C. Marshall Parkway.