Pennsylvania Route 880 is a 25-mile-long (40 km) state highway located in Centre, Clinton, and Lycoming counties in Pennsylvania. The southern terminus is at PA 192 in Miles Township. The northern terminus is at PA 44 in Limestone Township Though it does not have a direct junction with Interstate 80 (I-80), it underpasses the highway in Carroll and drivers can enter I-80 one mile (1.6 km) east by turning left onto East Valley Road. South of this intersection, PA 880 is known as East Valley Road until Loganton, where it becomes Main Street. South of Loganton it continues as West Valley Road until the Centre County line. From there until its southern terminus it serves as Broad Street in Rebersburg. North of the East Valley Road intersection, PA 880 becomes Rauchtown Road until entering Lycoming County.

Clinton County is a county in the Commonwealth of Pennsylvania. As of the 2020 census, the population was 37,450. Its county seat is Lock Haven. The county was created on June 21, 1839, from parts of Centre and Lycoming Counties. Its name is in honor of the sixth Governor of New York, DeWitt Clinton. Some alternate sources suggest the namesake is Henry Clinton. Clinton County comprises the Lock Haven, PA Micropolitan Statistical Area, which is also included in the Williamsport-Lock Haven, PA Combined Statistical Area. The county is part of the Central Pennsylvania region of the state.