Pensacola International Airport, formerly Pensacola Gulf Coast Regional Airport and Pensacola Regional Airport, and temporarily branded Pensacola Intergalactic Airport each February in recognition of the local Pensacon convention, is a public use airport three nautical miles northeast of the central business district of Pensacola, in Escambia County, Florida, United States. It is owned by the City of Pensacola. Despite its name, the airport does not offer scheduled international flights, though chartered international flights are not uncommon. This airport is one of the five major airports in North Florida, and among these is the second largest by passenger count, only behind Jacksonville. The other airports in the North Florida region are: Northwest Florida Beaches International Airport, Destin-Fort Walton Beach Airport, Tallahassee International Airport, and Jacksonville International Airport.

Escambia County is the westernmost and oldest county in the U.S. state of Florida. It is in the state's northwestern corner. At the 2020 census, the population was 321,905. Its county seat and largest city is Pensacola. Escambia County is included within the Pensacola—Ferry Pass—Brent, Florida Metropolitan Statistical Area. The county population has continued to increase as the suburbs of Pensacola have developed.