The Pensacola culture was a regional variation of the Mississippian culture along the Gulf Coast of the United States that lasted from 1100 to 1700 CE. The archaeological culture covers an area stretching from a transitional Pensacola/Fort Walton culture zone at Choctawhatchee Bay in Florida to the eastern side of the Mississippi River Delta near Biloxi, Mississippi, with the majority of its sites located along Mobile Bay in the Mobile-Tensaw River Delta. Sites for the culture stretched inland, north into the southern Tombigee and Alabama River valleys, as far as the vicinity of Selma, Alabama.

The Fort Walton culture is the term used by archaeologists for a late prehistoric Native American archaeological culture that flourished in southeastern North America from approximately 1200~1500 CE and is associated with the historic Apalachee people.