Penwortham is a town and civil parish in South Ribble, Lancashire, England, on the south bank of the River Ribble facing the city of Preston. The town is at the most westerly crossing point of the river, with major road and rail links crossing it here. The population of the town at the 2011 census was 23,047.

South Ribble is a local government district with borough status in Lancashire, England. Its council is based in Leyland. The borough also includes the towns and villages of Penwortham, Leyland, Farington, Hutton, Longton, Walmer Bridge, Salmesbury, Lostock Hall, Walton le Dale and Bamber Bridge. Many of the built-up areas in the borough form part of the wider Preston built-up area.