The Pequot War was an armed conflict that took place in 1636 and ended in 1638 in New England, between the Pequot tribe and an alliance of the colonists from the Massachusetts Bay, Plymouth, and Saybrook colonies and their allies from the Narragansett and Mohegan tribes. The war concluded with the decisive defeat of the Pequot. At the end, about 700 Pequots had been killed or taken into captivity. Hundreds of prisoners were sold into slavery to colonists in Bermuda or the West Indies; other survivors were dispersed as captives to the victorious tribes.

Plymouth Colony was the first permanent English colony in New England from 1620 and the third permanent English colony in America, after Newfoundland and the Jamestown Colony. It was settled by the passengers on the Mayflower at a location that had previously been surveyed and named by Captain John Smith. The settlement served as the capital of the colony and developed as the town of Plymouth, Massachusetts. At its height, Plymouth Colony occupied most of the southeastern portion of Massachusetts. Many of the people and events surrounding Plymouth Colony have become part of American folklore, including the American tradition of Thanksgiving and the monument of Plymouth Rock.