In histology, histopathology, and clinical pathology, Perls Prussian blue is a commonly used method to detect the presence of iron in tissue or cell samples. Perls Prussian Blue derives its name from
Cerebrospinal fluid specimen stained with Perls Prussian blue showing iron containing macrophage (stained blue) surrounded by erythrocytes (stained red)
Section of liver stained with Perls Prussian blue, showing iron accumulations (blue) consistent with homozygous genetic hemochromatosis
Perls Prussian blue components: potassium ferrocyanide and hydrochloric acid.
Perls Prussian blue stained section of liver biopsy showing hemosiderosis
Histopathology is the microscopic examination of tissue in order to study the manifestations of disease. Specifically, in clinical medicine, histopathology refers to the examination of a biopsy or sur
Perls Prussian blue
…In histology, histopathology, and clinical pathology, Perls Prussian blue is a commonly used method to detect the presence of iron in tissue or cell samples. Perls Prussian Blue…
Microscope image showing contraction band necrosis, a histopathologic finding of myocardial infarction (heart attack).
Items used for submitting specimens: (Biopsy) wrap, (biopsy) sponge, (tissue processing) cassette and (biopsy) bag.
There is also the option to make a "touch prep", wherein a glass slide is simply pressed against the tissue and then exposed to a fixative solution. The glass slide can then be stained and examined. This is feasible for an initial evaluation of suspected lymphomas.
Orientation (lowest magnification): In this case oriented by the skin surface (green). A lesion is seen (red) and its demarcation can be discerned (diffuse in this case)