Perry County is a county located in the southwestern part of the U.S. state of Indiana. As of 2020, the population was 19,170. The county seat is Tell City. It is the hilliest county as well as one of the most forested counties in Indiana as it features more than 60,000 acres (240 km2) of Hoosier National Forest. The Ohio River Scenic Byway along Indiana State Road 66 runs along the southern border of the county while Interstate 64 traverses the northern portion of the county. Connecting the two is Indiana State Road 37.

Southwestern Indiana is an 11-county region of southern Indiana, United States located at the southernmost and westernmost part of the state. As of the 2010 census, the region's combined population is 474,251. Evansville, Indiana's third-largest city, is the primary hub for the region, as well as the primary regional hub for a tri-state area that includes Kentucky and Illinois. Other regional hubs include Jasper, Vincennes, and Washington. Although part of a Midwestern state, this region's culture and language, like much of the rest of Southern Indiana, is aligned more with that of the Upland South rather than the Midwest.