Perry County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 18,956. Its county seat is Perryville. The county was officially organized on November 16, 1820 from Ste. Genevieve County and was named after Oliver Hazard Perry, a naval hero of the War of 1812.

Apple Creek is a stream that rises in western Perry County, Missouri and empties into the Mississippi River, forming the boundary between Perry and Cape Girardeau counties.