Perryville is a city in and the county seat of Perry County, Arkansas, United States. The population was 1,460 at the 2010 census, an increase of just two persons from 2000. It is part of the Little Rock–North Little Rock–Conway Metropolitan Statistical Area.

Perry County is a county located in the U.S. state of Arkansas. Its population was 10,019 at the 2020 United States Census. The county seat is Perryville. The county was formed on December 18, 1840, and named for Commodore Oliver Hazard Perry, naval hero in the War of 1812. It is an alcohol prohibition or dry county.