Perryville is a city in Perry County, Missouri, United States. The population was 8,555 at the 2020 United States census. Perryville is the county seat of Perry County.

Perry County is a county located in the southeastern portion of the U.S. state of Missouri. As of the 2020 census, the population was 18,956. Its county seat is Perryville. The county was officially organized on November 16, 1820 from Ste. Genevieve County and was named after Oliver Hazard Perry, a naval hero of the War of 1812.