Perseus was king of the ancient kingdom of Macedon from 179 until 168 BC. He is widely regarded as the last king of Macedonia and the last ruler from the Antigonid Dynasty, as his defeat by Rome at the Battle of Pydna during the Third Macedonian War effectively ended Macedonia as an independent political entity.

The Antigonid dynasty was a Macedonian Greek royal house which ruled the kingdom of Macedon during the Hellenistic period. Founded by Antigonus I Monophthalmus, a general and successor of Alexander the Great, the dynasty first came to power after the Battle of Salamis in 306 BC and ruled much of Hellenistic Greece from 294 until their defeat at the Battle of Pydna in 168 BC, after which Macedon came under the control of the Roman Republic.