The Persian embassy to Europe (1599–1602) was dispatched by the Persian Shah Abbas I in 1599 to obtain an alliance against the Ottoman Empire. The Persians had then been at war with the Ottoman Empire for more than a century, and so decided to try to obtain European help against the Ottomans. Besides the territorial antagonism of the Ottoman and Persian realms, there was also strong religious antagonism, as the Persians proclaimed Shiism against the Ottoman Empire's Sunnism. The objective of the mission was to establish a European–Persian alliance against the Ottoman Turks. These Persian efforts at rapprochement with Europe followed the Persian defeat against the Ottoman Empire in the Ottoman–Safavid War (1578–1590).

Abbas I, commonly known as Abbas the Great, was the fifth shah of Safavid Iran from 1588 to 1629. The third son of Shah Mohammad Khodabanda, he is generally considered one of the greatest rulers of Iranian history and the Safavid dynasty.