Perth Amboy High School is a four-year comprehensive community public high school which serves students in ninth through twelfth grades from Perth Amboy in Middlesex County, in the U.S. state of New Jersey, operating as the lone secondary school of the Perth Amboy Public Schools. The school has been accredited by the Middle States Association of Colleges and Schools Commission on Elementary and Secondary Schools since 1928.

Perth Amboy is a city in northeastern Middlesex County, in the U.S. state of New Jersey, within the New York metropolitan area. As of the 2020 United States census, the city's population was 55,436. Perth Amboy is known as the "City by the Bay", referring to its location adjoining Raritan Bay.