Pescadero Creek is a major stream in Santa Cruz and San Mateo counties in California, United States. At 26.6 miles (42.8 km), it is the longest stream in San Mateo County and flows all year from springs in the Santa Cruz Mountains. Its source is at 1,880 feet (570 m) above sea level on the western edge of Castle Rock State Park, with additional headwaters in Portola Redwoods State Park, and its course traverses Pescadero Creek County Park and San Mateo County Memorial Park before entering Pescadero Marsh Natural Preserve at Pescadero State Beach and thence to the Pacific Ocean 14.4 miles (23 km) south of Half Moon Bay.

Portola Redwoods State Park is a 2,800 acres (1,100 ha) state park in California situated in San Mateo County. The parks' primary watercourses — Peters Creek, Pescadero Creek and their associated tributaries — converge at Portola Redwoods State Park. Tip Toe Falls is a small waterfall along Fall Creek, a tributary of Pescadero Creek.