The Pettigrew Home & Museum is a historic house museum located at 131 North Duluth Avenue in the Cathedral Historic District of Sioux Falls, South Dakota. Built in 1889, it was once the home of United States Senator Richard Franklin Pettigrew, for whom it is now named. The home was later turned into a museum that is open to the public.

Richard Franklin Pettigrew was an American lawyer, surveyor, and land developer. He represented the Dakota Territory in the U.S. Congress and, after the Dakotas were admitted as States, he was the first U.S. Senator from South Dakota.