Pharnaces II of Pontus was the king of the Bosporan Kingdom and Kingdom of Pontus until his death. He was a monarch of Persian and Greek ancestry. He was the youngest child born to King Mithridates VI of Pontus from his first wife, his sister Queen Laodice. He was born and raised in the Kingdom of Pontus and was the namesake of his late double great grandfather Pharnaces I of Pontus. After his father was defeated by the Romans in the Third Mithridatic War and died in 63 BC, the Romans annexed the western part of Pontus, merged it with the former Kingdom of Bithynia and formed the Roman province of Bithynia and Pontus. The eastern part of Pontus remained under the rule of Pharnaces as a client kingdom until his death.

Mithridates or Mithradates VI Eupator was the ruler of the Kingdom of Pontus in northern Anatolia from 120 to 63 BC, and one of the Roman Republic's most formidable and determined opponents. He was an effective, ambitious and ruthless ruler who sought to dominate Asia Minor and the Black Sea region, waging several hard-fought but ultimately unsuccessful wars to break Roman dominion over Asia and the Hellenic world. He has been called the greatest ruler of the Kingdom of Pontus. He cultivated an immunity to poisons by regularly ingesting sub-lethal doses; this practice, now called mithridatism, is named after him. After his death, he became known as Mithridates the Great.