Phenacodus is an extinct genus of mammals from the late Paleocene through middle Eocene, about 55 million years ago. It is one of the earliest and most primitive of the ungulates, typifying the family Phenacodontidae and the order Perissodactyla.

Phenacodontidae is an extinct family of large herbivorous mammals traditionally placed in the “wastebasket taxon” Condylarthra, which may instead represent early-stage perissodactyls. They lived from the late early Paleocene to early middle Eocene and their fossil remains have been found in North America and Europe. The only unequivocal Asian phenacodontid is Lophocion asiaticus.