1.
Biphenyl
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Biphenyl is an organic compound that forms colorless crystals. Particularly in older literature, compounds containing the group consisting of biphenyl less one hydrogen may use the prefixes xenyl or diphenylyl. It has a pleasant smell. Biphenyl is a hydrocarbon with a molecular formula 2. It is notable as a material for the production of polychlorinated biphenyls. Biphenyl is also an intermediate for the production of a host of organic compounds such as emulsifiers, optical brighteners, crop protection products. Biphenyl is insoluble in water, but soluble in organic solvents. The biphenyl molecule consists of two connected phenyl rings, in the laboratory, biphenyl can also be synthesized by treating phenylmagnesium bromide with copper salts. Biphenyl occurs naturally in coal tar, crude oil, and natural gas, lacking functional groups, biphenyl is fairly non-reactive, which is the basis of its main application. Biphenyl is mainly used as a transfer agent as a eutectic mixture with diphenylether. This mixture is stable to 400 °C, Biphenyl does undergo sulfonation followed by base hydrolysis produces p-hydroxybiphenyl and p, p′-dihydroxybiphenyl, which are useful fungicides. In another substitution reactions, it undergoes halogenation, polychlorinated biphenyls were once popular pesticides. Rotation about the bond in biphenyl, and especially its ortho-substituted derivatives, is sterically hindered. For this reason, some substituted biphenyls show atropisomerism, that is, some derivatives, as well as related molecules such as BINAP, find application as ligands in asymmetric synthesis. In the case of unsubstituted biphenyl, the torsional angle is 44. 4°. Adding ortho substituents greatly increases the barrier, in the case of the 2, 2-dimethyl derivative, Biphenyl prevents the growth of molds and fungus, and is therefore used as a preservative, particularly in the preservation of citrus fruits during transportation. It is no longer approved as an additive in the European Union. It is mildly toxic, but can be degraded biologically by conversion into nontoxic compounds, some bacteria are able to hydroxylate biphenyl and its polychlorinated biphenyls
2.
Jmol
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Jmol is computer software for molecular modelling chemical structures in 3-dimensions. Jmol returns a 3D representation of a molecule that may be used as a teaching tool and it is written in the programming language Java, so it can run on the operating systems Windows, macOS, Linux, and Unix, if Java is installed. It is free and open-source software released under a GNU Lesser General Public License version 2.0, a standalone application and a software development kit exist that can be integrated into other Java applications, such as Bioclipse and Taverna. A popular feature is an applet that can be integrated into web pages to display molecules in a variety of ways, for example, molecules can be displayed as ball-and-stick models, space-filling models, ribbon diagrams, etc. Jmol supports a range of chemical file formats, including Protein Data Bank, Crystallographic Information File, MDL Molfile. There is also a JavaScript-only version, JSmol, that can be used on computers with no Java, the Jmol applet, among other abilities, offers an alternative to the Chime plug-in, which is no longer under active development. While Jmol has many features that Chime lacks, it does not claim to reproduce all Chime functions, most notably, Chime requires plug-in installation and Internet Explorer 6.0 or Firefox 2.0 on Microsoft Windows, or Netscape Communicator 4.8 on Mac OS9. Jmol requires Java installation and operates on a variety of platforms. For example, Jmol is fully functional in Mozilla Firefox, Internet Explorer, Opera, Google Chrome, fast and Scriptable Molecular Graphics in Web Browsers without Java3D
3.
ChEMBL
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ChEMBL or ChEMBLdb is a manually curated chemical database of bioactive molecules with drug-like properties. It is maintained by the European Bioinformatics Institute, of the European Molecular Biology Laboratory, based at the Wellcome Trust Genome Campus, Hinxton, the database, originally known as StARlite, was developed by a biotechnology company called Inpharmatica Ltd. later acquired by Galapagos NV. The data was acquired for EMBL in 2008 with an award from The Wellcome Trust, resulting in the creation of the ChEMBL chemogenomics group at EMBL-EBI, the ChEMBL database contains compound bioactivity data against drug targets. Bioactivity is reported in Ki, Kd, IC50, and EC50, data can be filtered and analyzed to develop compound screening libraries for lead identification during drug discovery. ChEMBL version 2 was launched in January 2010, including 2.4 million bioassay measurements covering 622,824 compounds and this was obtained from curating over 34,000 publications across twelve medicinal chemistry journals. ChEMBLs coverage of available bioactivity data has grown to become the most comprehensive ever seen in a public database, in October 2010 ChEMBL version 8 was launched, with over 2.97 million bioassay measurements covering 636,269 compounds. ChEMBL_10 saw the addition of the PubChem confirmatory assays, in order to integrate data that is comparable to the type, ChEMBLdb can be accessed via a web interface or downloaded by File Transfer Protocol. It is formatted in a manner amenable to computerized data mining, ChEMBL is also integrated into other large-scale chemistry resources, including PubChem and the ChemSpider system of the Royal Society of Chemistry. In addition to the database, the ChEMBL group have developed tools and these include Kinase SARfari, an integrated chemogenomics workbench focussed on kinases. The system incorporates and links sequence, structure, compounds and screening data, the primary purpose of ChEMBL-NTD is to provide a freely accessible and permanent archive and distribution centre for deposited data. July 2012 saw the release of a new data service, sponsored by the Medicines for Malaria Venture. The data in this service includes compounds from the Malaria Box screening set, myChEMBL, the ChEMBL virtual machine, was released in October 2013 to allow users to access a complete and free, easy-to-install cheminformatics infrastructure. In December 2013, the operations of the SureChem patent informatics database were transferred to EMBL-EBI, in a portmanteau, SureChem was renamed SureChEMBL. 2014 saw the introduction of the new resource ADME SARfari - a tool for predicting and comparing cross-species ADME targets
4.
ChemSpider
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ChemSpider is a database of chemicals. ChemSpider is owned by the Royal Society of Chemistry, the database contains information on more than 50 million molecules from over 500 data sources including, Each chemical is given a unique identifier, which forms part of a corresponding URL. This is an approach to develop an online chemistry database. The search can be used to widen or restrict already found results, structure searching on mobile devices can be done using free apps for iOS and for the Android. The ChemSpider database has been used in combination with text mining as the basis of document markup. The result is a system between chemistry documents and information look-up via ChemSpider into over 150 data sources. ChemSpider was acquired by the Royal Society of Chemistry in May,2009, prior to the acquisition by RSC, ChemSpider was controlled by a private corporation, ChemZoo Inc. The system was first launched in March 2007 in a release form. ChemSpider has expanded the generic support of a database to include support of the Wikipedia chemical structure collection via their WiChempedia implementation. A number of services are available online. SyntheticPages is an interactive database of synthetic chemistry procedures operated by the Royal Society of Chemistry. Users submit synthetic procedures which they have conducted themselves for publication on the site and these procedures may be original works, but they are more often based on literature reactions. Citations to the published procedure are made where appropriate. They are checked by an editor before posting. The pages do not undergo formal peer-review like a journal article. The comments are moderated by scientific editors. The intention is to collect practical experience of how to conduct useful chemical synthesis in the lab, while experimental methods published in an ordinary academic journal are listed formally and concisely, the procedures in ChemSpider SyntheticPages are given with more practical detail. Comments by submitters are included as well, other publications with comparable amounts of detail include Organic Syntheses and Inorganic Syntheses
5.
DrugBank
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The DrugBank database is a comprehensive, freely accessible, online database containing information on drugs and drug targets. As both a bioinformatics and a resource, DrugBank combines detailed drug data with comprehensive drug target information. Because of its scope, comprehensive referencing and unusually detailed data descriptions. As a result, links to DrugBank are maintained for nearly all drugs listed in Wikipedia, DrugBank is widely used by the drug industry, medicinal chemists, pharmacists, physicians, students and the general public. Its extensive drug and drug-target data has enabled the discovery and repurposing of a number of existing drugs to treat rare, the latest release of the database contains 8227 drug entries including 2003 FDA-approved small molecule drugs,221 FDA-approved biotech drugs,93 nutraceuticals and over 6000 experimental drugs. Additionally,4270 non-redundant protein sequences are linked to these drug entries, each DrugCard entry contains more than 200 data fields with half of the information being devoted to drug/chemical data and the other half devoted to drug target or protein data. Four additional databases, HMDB, T3DB, SMPDB and FooDB are also part of a suite of metabolomic/cheminformatic databases. The first version of DrugBank was released in 2006 and this early release contained relatively modest information about 841 FDA-approved small molecule drugs and 113 biotech drugs. It also included information on 2133 drug targets, the second version of DrugBank was released in 2009. This greatly expanded and improved version of the database included 1344 approved small molecule drugs and 123 biotech drugs as well as 3037 unique drug targets. Version 2.0 also included, for the first time, withdrawn drugs and illicit drugs, version 3.0 was released in 2011. This version contained 1424 approved small molecule drugs and 132 biotech drugs as well as >4000 unique drug targets, version 3.0 also included drug transporter data, drug pathway data, drug pricing, patent and manufacturing data as well as data on >5000 experimental drugs. Version 4.0 was released in 2014 and this version included 1558 FDA-approved small molecule drugs,155 biotech drugs and 4200 unique drug targets. Version 4.0 also incorporated information on drug metabolites, drug taxonomy, drug spectra, drug binding constants. Table 1 provides a complete statistical summary of the history of DrugBank’s development. All data in DrugBank is non-proprietary or is derived from a non-proprietary source and it is freely accessible and available to anyone. In addition, nearly every item is fully traceable and explicitly referenced to the original source. DrugBank data is available through a web interface and downloads
6.
European Chemicals Agency
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ECHA is the driving force among regulatory authorities in implementing the EUs chemicals legislation. ECHA helps companies to comply with the legislation, advances the safe use of chemicals, provides information on chemicals and it is located in Helsinki, Finland. The Agency, headed by Executive Director Geert Dancet, started working on 1 June 2007, the REACH Regulation requires companies to provide information on the hazards, risks and safe use of chemical substances that they manufacture or import. Companies register this information with ECHA and it is freely available on their website. So far, thousands of the most hazardous and the most commonly used substances have been registered, the information is technical but gives detail on the impact of each chemical on people and the environment. This also gives European consumers the right to ask whether the goods they buy contain dangerous substances. The Classification, Labelling and Packaging Regulation introduces a globally harmonised system for classifying and labelling chemicals into the EU. This worldwide system makes it easier for workers and consumers to know the effects of chemicals, companies need to notify ECHA of the classification and labelling of their chemicals. So far, ECHA has received over 5 million notifications for more than 100000 substances, the information is freely available on their website. Consumers can check chemicals in the products they use, Biocidal products include, for example, insect repellents and disinfectants used in hospitals. The Biocidal Products Regulation ensures that there is information about these products so that consumers can use them safely. ECHA is responsible for implementing the regulation, the law on Prior Informed Consent sets guidelines for the export and import of hazardous chemicals. Through this mechanism, countries due to hazardous chemicals are informed in advance and have the possibility of rejecting their import. Substances that may have effects on human health and the environment are identified as Substances of Very High Concern 1. These are mainly substances which cause cancer, mutation or are toxic to reproduction as well as substances which persist in the body or the environment, other substances considered as SVHCs include, for example, endocrine disrupting chemicals. Companies manufacturing or importing articles containing these substances in a concentration above 0 and they are required to inform users about the presence of the substance and therefore how to use it safely. Consumers have the right to ask the retailer whether these substances are present in the products they buy, once a substance has been officially identified in the EU as being of very high concern, it will be added to a list. This list is available on ECHA’s website and shows consumers and industry which chemicals are identified as SVHCs, Substances placed on the Candidate List can then move to another list
7.
PubChem
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PubChem is a database of chemical molecules and their activities against biological assays. The system is maintained by the National Center for Biotechnology Information, a component of the National Library of Medicine, PubChem can be accessed for free through a web user interface. Millions of compound structures and descriptive datasets can be downloaded via FTP. PubChem contains substance descriptions and small molecules with fewer than 1000 atoms and 1000 bonds, more than 80 database vendors contribute to the growing PubChem database. PubChem consists of three dynamically growing primary databases, as of 28 January 2016, Compounds,82.6 million entries, contains pure and characterized chemical compounds. Substances,198 million entries, contains also mixtures, extracts, complexes, bioAssay, bioactivity results from 1.1 million high-throughput screening programs with several million values. PubChem contains its own online molecule editor with SMILES/SMARTS and InChI support that allows the import and export of all common chemical file formats to search for structures and fragments. In the text search form the database fields can be searched by adding the name in square brackets to the search term. A numeric range is represented by two separated by a colon. The search terms and field names are case-insensitive, parentheses and the logical operators AND, OR, and NOT can be used. AND is assumed if no operator is used, example,0,5000,50,10 -5,5 PubChem was released in 2004. The American Chemical Society has raised concerns about the publicly supported PubChem database and they have a strong interest in the issue since the Chemical Abstracts Service generates a large percentage of the societys revenue. To advocate their position against the PubChem database, ACS has actively lobbied the US Congress, soon after PubChems creation, the American Chemical Society lobbied U. S. Congress to restrict the operation of PubChem, which they asserted competes with their Chemical Abstracts Service
8.
International Chemical Identifier
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Initially developed by IUPAC and NIST from 2000 to 2005, the format and algorithms are non-proprietary. The continuing development of the standard has supported since 2010 by the not-for-profit InChI Trust. The current version is 1.04 and was released in September 2011, prior to 1.04, the software was freely available under the open source LGPL license, but it now uses a custom license called IUPAC-InChI Trust License. Not all layers have to be provided, for instance, the layer can be omitted if that type of information is not relevant to the particular application. InChIs can thus be seen as akin to a general and extremely formalized version of IUPAC names and they can express more information than the simpler SMILES notation and differ in that every structure has a unique InChI string, which is important in database applications. Information about the 3-dimensional coordinates of atoms is not represented in InChI, the InChI algorithm converts input structural information into a unique InChI identifier in a three-step process, normalization, canonicalization, and serialization. The InChIKey, sometimes referred to as a hashed InChI, is a fixed length condensed digital representation of the InChI that is not human-understandable. The InChIKey specification was released in September 2007 in order to facilitate web searches for chemical compounds and it should be noted that, unlike the InChI, the InChIKey is not unique, though collisions can be calculated to be very rare, they happen. In January 2009 the final 1.02 version of the InChI software was released and this provided a means to generate so called standard InChI, which does not allow for user selectable options in dealing with the stereochemistry and tautomeric layers of the InChI string. The standard InChIKey is then the hashed version of the standard InChI string, the standard InChI will simplify comparison of InChI strings and keys generated by different groups, and subsequently accessed via diverse sources such as databases and web resources. Every InChI starts with the string InChI= followed by the version number and this is followed by the letter S for standard InChIs. The remaining information is structured as a sequence of layers and sub-layers, the layers and sub-layers are separated by the delimiter / and start with a characteristic prefix letter. The six layers with important sublayers are, Main layer Chemical formula and this is the only sublayer that must occur in every InChI. The atoms in the formula are numbered in sequence, this sublayer describes which atoms are connected by bonds to which other ones. Describes how many hydrogen atoms are connected to each of the other atoms, the condensed,27 character standard InChIKey is a hashed version of the full standard InChI, designed to allow for easy web searches of chemical compounds. Most chemical structures on the Web up to 2007 have been represented as GIF files, the full InChI turned out to be too lengthy for easy searching, and therefore the InChIKey was developed. With all databases currently having below 50 million structures, such duplication appears unlikely at present, a recent study more extensively studies the collision rate finding that the experimental collision rate is in agreement with the theoretical expectations. Example, Morphine has the structure shown on the right, as the InChI cannot be reconstructed from the InChIKey, an InChIKey always needs to be linked to the original InChI to get back to the original structure
9.
Simplified molecular-input line-entry system
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The simplified molecular-input line-entry system is a specification in form of a line notation for describing the structure of chemical species using short ASCII strings. SMILES strings can be imported by most molecule editors for conversion back into two-dimensional drawings or three-dimensional models of the molecules, the original SMILES specification was initiated in the 1980s. It has since modified and extended. In 2007, a standard called OpenSMILES was developed in the open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, the original SMILES specification was initiated by David Weininger at the USEPA Mid-Continent Ecology Division Laboratory in Duluth in the 1980s. The Environmental Protection Agency funded the project to develop SMILES. It has since modified and extended by others, most notably by Daylight Chemical Information Systems. In 2007, a standard called OpenSMILES was developed by the Blue Obelisk open-source chemistry community. Other linear notations include the Wiswesser Line Notation, ROSDAL and SLN, in July 2006, the IUPAC introduced the InChI as a standard for formula representation. SMILES is generally considered to have the advantage of being slightly more human-readable than InChI, the term SMILES refers to a line notation for encoding molecular structures and specific instances should strictly be called SMILES strings. However, the term SMILES is also used to refer to both a single SMILES string and a number of SMILES strings, the exact meaning is usually apparent from the context. The terms canonical and isomeric can lead to confusion when applied to SMILES. The terms describe different attributes of SMILES strings and are not mutually exclusive, typically, a number of equally valid SMILES strings can be written for a molecule. For example, CCO, OCC and CC all specify the structure of ethanol, algorithms have been developed to generate the same SMILES string for a given molecule, of the many possible strings, these algorithms choose only one of them. This SMILES is unique for each structure, although dependent on the algorithm used to generate it. These algorithms first convert the SMILES to a representation of the molecular structure. A common application of canonical SMILES is indexing and ensuring uniqueness of molecules in a database, there is currently no systematic comparison across commercial software to test if such flaws exist in those packages. SMILES notation allows the specification of configuration at tetrahedral centers, and these are structural features that cannot be specified by connectivity alone and SMILES which encode this information are termed isomeric SMILES
10.
Chemical formula
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These are limited to a single typographic line of symbols, which may include subscripts and superscripts. A chemical formula is not a name, and it contains no words. Although a chemical formula may imply certain simple chemical structures, it is not the same as a full chemical structural formula. Chemical formulas can fully specify the structure of only the simplest of molecules and chemical substances, the simplest types of chemical formulas are called empirical formulas, which use letters and numbers indicating the numerical proportions of atoms of each type. Molecular formulas indicate the numbers of each type of atom in a molecule. For example, the formula for glucose is CH2O, while its molecular formula is C6H12O6. This is possible if the relevant bonding is easy to show in one dimension, an example is the condensed molecular/chemical formula for ethanol, which is CH3-CH2-OH or CH3CH2OH. For reasons of structural complexity, there is no condensed chemical formula that specifies glucose, chemical formulas may be used in chemical equations to describe chemical reactions and other chemical transformations, such as the dissolving of ionic compounds into solution. A chemical formula identifies each constituent element by its chemical symbol, in empirical formulas, these proportions begin with a key element and then assign numbers of atoms of the other elements in the compound, as ratios to the key element. For molecular compounds, these numbers can all be expressed as whole numbers. For example, the formula of ethanol may be written C2H6O because the molecules of ethanol all contain two carbon atoms, six hydrogen atoms, and one oxygen atom. Some types of compounds, however, cannot be written with entirely whole-number empirical formulas. An example is boron carbide, whose formula of CBn is a variable non-whole number ratio with n ranging from over 4 to more than 6.5. When the chemical compound of the consists of simple molecules. These types of formulas are known as molecular formulas and condensed formulas. A molecular formula enumerates the number of atoms to reflect those in the molecule, so that the formula for glucose is C6H12O6 rather than the glucose empirical formula. However, except for very simple substances, molecular chemical formulas lack needed structural information, for simple molecules, a condensed formula is a type of chemical formula that may fully imply a correct structural formula. For example, ethanol may be represented by the chemical formula CH3CH2OH
11.
Density
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The density, or more precisely, the volumetric mass density, of a substance is its mass per unit volume. The symbol most often used for density is ρ, although the Latin letter D can also be used. Mathematically, density is defined as mass divided by volume, ρ = m V, where ρ is the density, m is the mass, and V is the volume. In some cases, density is defined as its weight per unit volume. For a pure substance the density has the numerical value as its mass concentration. Different materials usually have different densities, and density may be relevant to buoyancy, purity, osmium and iridium are the densest known elements at standard conditions for temperature and pressure but certain chemical compounds may be denser. Thus a relative density less than one means that the floats in water. The density of a material varies with temperature and pressure and this variation is typically small for solids and liquids but much greater for gases. Increasing the pressure on an object decreases the volume of the object, increasing the temperature of a substance decreases its density by increasing its volume. In most materials, heating the bottom of a results in convection of the heat from the bottom to the top. This causes it to rise relative to more dense unheated material, the reciprocal of the density of a substance is occasionally called its specific volume, a term sometimes used in thermodynamics. Density is a property in that increasing the amount of a substance does not increase its density. Archimedes knew that the irregularly shaped wreath could be crushed into a cube whose volume could be calculated easily and compared with the mass, upon this discovery, he leapt from his bath and ran naked through the streets shouting, Eureka. As a result, the term eureka entered common parlance and is used today to indicate a moment of enlightenment, the story first appeared in written form in Vitruvius books of architecture, two centuries after it supposedly took place. Some scholars have doubted the accuracy of this tale, saying among other things that the method would have required precise measurements that would have been difficult to make at the time, from the equation for density, mass density has units of mass divided by volume. As there are units of mass and volume covering many different magnitudes there are a large number of units for mass density in use. The SI unit of kilogram per metre and the cgs unit of gram per cubic centimetre are probably the most commonly used units for density.1,000 kg/m3 equals 1 g/cm3. In industry, other larger or smaller units of mass and or volume are often more practical, see below for a list of some of the most common units of density
12.
Melting point
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The melting point of a solid is the temperature at which it changes state from solid to liquid at atmospheric pressure. At the melting point the solid and liquid phase exist in equilibrium, the melting point of a substance depends on pressure and is usually specified at standard pressure. When considered as the temperature of the change from liquid to solid. Because of the ability of some substances to supercool, the point is not considered as a characteristic property of a substance. For most substances, melting and freezing points are approximately equal, for example, the melting point and freezing point of mercury is 234.32 kelvins. However, certain substances possess differing solid-liquid transition temperatures, for example, agar melts at 85 °C and solidifies from 31 °C to 40 °C, such direction dependence is known as hysteresis. The melting point of ice at 1 atmosphere of pressure is close to 0 °C. In the presence of nucleating substances the freezing point of water is the same as the melting point, the chemical element with the highest melting point is tungsten, at 3687 K, this property makes tungsten excellent for use as filaments in light bulbs. Many laboratory techniques exist for the determination of melting points, a Kofler bench is a metal strip with a temperature gradient. Any substance can be placed on a section of the strip revealing its thermal behaviour at the temperature at that point, differential scanning calorimetry gives information on melting point together with its enthalpy of fusion. A basic melting point apparatus for the analysis of crystalline solids consists of an oil bath with a transparent window, the several grains of a solid are placed in a thin glass tube and partially immersed in the oil bath. The oil bath is heated and with the aid of the melting of the individual crystals at a certain temperature can be observed. In large/small devices, the sample is placed in a heating block, the measurement can also be made continuously with an operating process. For instance, oil refineries measure the point of diesel fuel online, meaning that the sample is taken from the process. This allows for more frequent measurements as the sample does not have to be manually collected, for refractory materials the extremely high melting point may be determined by heating the material in a black body furnace and measuring the black-body temperature with an optical pyrometer. For the highest melting materials, this may require extrapolation by several hundred degrees, the spectral radiance from an incandescent body is known to be a function of its temperature. An optical pyrometer matches the radiance of a body under study to the radiance of a source that has been previously calibrated as a function of temperature, in this way, the measurement of the absolute magnitude of the intensity of radiation is unnecessary. However, known temperatures must be used to determine the calibration of the pyrometer, for temperatures above the calibration range of the source, an extrapolation technique must be employed
13.
Aqueous solution
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An aqueous solution is a solution in which the solvent is water. It is usually shown in chemical equations by appending to the relevant chemical formula, for example, a solution of table salt, or sodium chloride, in water would be represented as Na+ + Cl−. The word aqueous means pertaining to, related to, similar to, as water is an excellent solvent and is also naturally abundant, it is a ubiquitous solvent in chemistry. Substances that are hydrophobic often do not dissolve well in water, an example of a hydrophilic substance is sodium chloride. Acids and bases are aqueous solutions, as part of their Arrhenius definitions, the ability of a substance to dissolve in water is determined by whether the substance can match or exceed the strong attractive forces that water molecules generate between themselves. If the substance lacks the ability to dissolve in water the molecules form a precipitate, reactions in aqueous solutions are usually metathesis reactions. Metathesis reactions are another term for double-displacement, that is, when a cation displaces to form a bond with the other anion. The cation bonded with the latter anion will dissociate and bond with the other anion, aqueous solutions that conduct electric current efficiently contain strong electrolytes, while ones that conduct poorly are considered to have weak electrolytes. Those strong electrolytes are substances that are ionized in water. Nonelectrolytes are substances that dissolve in water yet maintain their molecular integrity, examples include sugar, urea, glycerol, and methylsulfonylmethane. When writing the equations of reactions, it is essential to determine the precipitate. To determine the precipitate, one must consult a chart of solubility, soluble compounds are aqueous, while insoluble compounds are the precipitate. Remember that there may not always be a precipitate, when performing calculations regarding the reacting of one or more aqueous solutions, in general one must know the concentration, or molarity, of the aqueous solutions. Solution concentration is given in terms of the form of the prior to it dissolving. Metal ions in aqueous solution Solubility Dissociation Acid-base reaction theories Properties of water Zumdahl S.1997, 4th ed. Boston, Houghton Mifflin Company
14.
Solubility
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Solubility is the property of a solid, liquid, or gaseous chemical substance called solute to dissolve in a solid, liquid, or gaseous solvent. The solubility of a substance depends on the physical and chemical properties of the solute and solvent as well as on temperature, pressure. The solubility of a substance is a different property from the rate of solution. Most often, the solvent is a liquid, which can be a substance or a mixture. One may also speak of solid solution, but rarely of solution in a gas, the extent of solubility ranges widely, from infinitely soluble such as ethanol in water, to poorly soluble, such as silver chloride in water. The term insoluble is often applied to poorly or very poorly soluble compounds, a common threshold to describe something as insoluble is less than 0.1 g per 100 mL of solvent. Under certain conditions, the solubility can be exceeded to give a so-called supersaturated solution. Metastability of crystals can also lead to apparent differences in the amount of a chemical that dissolves depending on its form or particle size. A supersaturated solution generally crystallises when seed crystals are introduced and rapid equilibration occurs, phenylsalicylate is one such simple observable substance when fully melted and then cooled below its fusion point. Solubility is not to be confused with the ability to dissolve a substance, for example, zinc dissolves in hydrochloric acid as a result of a chemical reaction releasing hydrogen gas in a displacement reaction. The zinc ions are soluble in the acid, the smaller a particle is, the faster it dissolves although there are many factors to add to this generalization. Crucially solubility applies to all areas of chemistry, geochemistry, inorganic, physical, organic, in all cases it will depend on the physical conditions and the enthalpy and entropy directly relating to the solvents and solutes concerned. By far the most common solvent in chemistry is water which is a solvent for most ionic compounds as well as a range of organic substances. This is a factor in acidity/alkalinity and much environmental and geochemical work. According to the IUPAC definition, solubility is the composition of a saturated solution expressed as a proportion of a designated solute in a designated solvent. Solubility may be stated in units of concentration such as molarity, molality, mole fraction, mole ratio, mass per volume. Solubility occurs under dynamic equilibrium, which means that solubility results from the simultaneous and opposing processes of dissolution, the solubility equilibrium occurs when the two processes proceed at a constant rate. The term solubility is used in some fields where the solute is altered by solvolysis
15.
GHS hazard pictograms
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Hazard pictograms form part of the international Globally Harmonized System of Classification and Labelling of Chemicals. Two sets of pictograms are included within the GHS, one for the labelling of containers and for workplace hazard warnings, either one or the other is chosen, depending on the target audience, but the two are not used together. The two sets of use the same symbols for the same hazards, although certain symbols are not required for transport pictograms. Transport pictograms come in variety of colors and may contain additional information such as a subcategory number. It has still to be implemented by the European Union in 2009, the following pictograms are included in the Worldwide Model Using but have not been incorporated into the GHS, ICZ and Catwallsh Hazcom Labelling because of the nature of the hazards. Globally Harmonized System of Classification and Labelling of Chemicals, New York and Geneva, United Nations,2007, ISBN 978-92-1-116957-7, ST/SG/AC. 10/30/Rev. Model Regulations, New York and Geneva, United Nations,2007, ISBN 978-92-1-139120-6, manual of Tests and Criteria, New York and Geneva, United Nations,2002, ISBN 92-1-139087-7, ST/SG/AC. 10/11/Rev.4 GHS pictogram gallery from the United Nations Economic Commission for Europe
16.
Chemical compound
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A chemical compound is an entity consisting of two or more atoms, at least two from different elements, which associate via chemical bonds. Many chemical compounds have a numerical identifier assigned by the Chemical Abstracts Service. For example, water is composed of two atoms bonded to one oxygen atom, the chemical formula is H2O. A compound can be converted to a different chemical composition by interaction with a chemical compound via a chemical reaction. In this process, bonds between atoms are broken in both of the compounds, and then bonds are reformed so that new associations are made between atoms. Schematically, this reaction could be described as AB + CD → AC + BD, where A, B, C, and D are each unique atoms, and AB, CD, AC, and BD are each unique compounds. A chemical element bonded to a chemical element is not a chemical compound since only one element. Examples are the diatomic hydrogen and the polyatomic molecule sulfur. Chemical compounds have a unique and defined chemical structure held together in a spatial arrangement by chemical bonds. Pure chemical elements are not considered chemical compounds, failing the two or more atom requirement, though they often consist of molecules composed of multiple atoms. There is varying and sometimes inconsistent nomenclature differentiating substances, which include truly non-stoichiometric examples, from chemical compounds, other compounds regarded as chemically identical may have varying amounts of heavy or light isotopes of the constituent elements, which changes the ratio of elements by mass slightly. Characteristic properties of compounds include that elements in a compound are present in a definite proportion, for example, the molecule of the compound water is composed of hydrogen and oxygen in a ratio of 2,1. In addition, compounds have a set of properties. The physical and chemical properties of compounds differ from those of their constituent elements, however, mixtures can be created by mechanical means alone, but a compound can be created only by a chemical reaction. Some mixtures are so combined that they have some properties similar to compounds. Other examples of compound-like mixtures include intermetallic compounds and solutions of metals in a liquid form of ammonia. Compounds may be described using formulas in various formats, for compounds that exist as molecules, the formula for the molecular unit is shown. For polymeric materials, such as minerals and many metal oxides, the elements in a chemical formula are normally listed in a specific order, called the Hill system
17.
Carbon
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Carbon is a chemical element with symbol C and atomic number 6. It is nonmetallic and tetravalent—making four electrons available to form covalent chemical bonds, three isotopes occur naturally, 12C and 13C being stable, while 14C is a radioactive isotope, decaying with a half-life of about 5,730 years. Carbon is one of the few elements known since antiquity, Carbon is the 15th most abundant element in the Earths crust, and the fourth most abundant element in the universe by mass after hydrogen, helium, and oxygen. It is the second most abundant element in the body by mass after oxygen. The atoms of carbon can bond together in different ways, termed allotropes of carbon, the best known are graphite, diamond, and amorphous carbon. The physical properties of carbon vary widely with the allotropic form, for example, graphite is opaque and black while diamond is highly transparent. Graphite is soft enough to form a streak on paper, while diamond is the hardest naturally occurring material known, graphite is a good electrical conductor while diamond has a low electrical conductivity. Under normal conditions, diamond, carbon nanotubes, and graphene have the highest thermal conductivities of all known materials, all carbon allotropes are solids under normal conditions, with graphite being the most thermodynamically stable form. They are chemically resistant and require high temperature to react even with oxygen, the most common oxidation state of carbon in inorganic compounds is +4, while +2 is found in carbon monoxide and transition metal carbonyl complexes. The largest sources of carbon are limestones, dolomites and carbon dioxide, but significant quantities occur in organic deposits of coal, peat, oil. For this reason, carbon has often referred to as the king of the elements. The allotropes of carbon graphite, one of the softest known substances, and diamond. It bonds readily with other small atoms including other carbon atoms, Carbon is known to form almost ten million different compounds, a large majority of all chemical compounds. Carbon also has the highest sublimation point of all elements, although thermodynamically prone to oxidation, carbon resists oxidation more effectively than elements such as iron and copper that are weaker reducing agents at room temperature. Carbon is the element, with a ground-state electron configuration of 1s22s22p2. Its first four ionisation energies,1086.5,2352.6,4620.5 and 6222.7 kJ/mol, are higher than those of the heavier group 14 elements. Carbons covalent radii are normally taken as 77.2 pm,66.7 pm and 60.3 pm, although these may vary depending on coordination number, in general, covalent radius decreases with lower coordination number and higher bond order. Carbon compounds form the basis of all life on Earth
18.
Hydrogen
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Hydrogen is a chemical element with chemical symbol H and atomic number 1. With a standard weight of circa 1.008, hydrogen is the lightest element on the periodic table. Its monatomic form is the most abundant chemical substance in the Universe, non-remnant stars are mainly composed of hydrogen in the plasma state. The most common isotope of hydrogen, termed protium, has one proton, the universal emergence of atomic hydrogen first occurred during the recombination epoch. At standard temperature and pressure, hydrogen is a colorless, odorless, tasteless, non-toxic, nonmetallic, since hydrogen readily forms covalent compounds with most nonmetallic elements, most of the hydrogen on Earth exists in molecular forms such as water or organic compounds. Hydrogen plays an important role in acid–base reactions because most acid-base reactions involve the exchange of protons between soluble molecules. In ionic compounds, hydrogen can take the form of a charge when it is known as a hydride. The hydrogen cation is written as though composed of a bare proton, Hydrogen gas was first artificially produced in the early 16th century by the reaction of acids on metals. Industrial production is mainly from steam reforming natural gas, and less often from more energy-intensive methods such as the electrolysis of water. Most hydrogen is used near the site of its production, the two largest uses being fossil fuel processing and ammonia production, mostly for the fertilizer market, Hydrogen is a concern in metallurgy as it can embrittle many metals, complicating the design of pipelines and storage tanks. Hydrogen gas is flammable and will burn in air at a very wide range of concentrations between 4% and 75% by volume. The enthalpy of combustion is −286 kJ/mol,2 H2 + O2 →2 H2O +572 kJ Hydrogen gas forms explosive mixtures with air in concentrations from 4–74%, the explosive reactions may be triggered by spark, heat, or sunlight. The hydrogen autoignition temperature, the temperature of spontaneous ignition in air, is 500 °C, the detection of a burning hydrogen leak may require a flame detector, such leaks can be very dangerous. Hydrogen flames in other conditions are blue, resembling blue natural gas flames, the destruction of the Hindenburg airship was a notorious example of hydrogen combustion and the cause is still debated. The visible orange flames in that incident were the result of a mixture of hydrogen to oxygen combined with carbon compounds from the airship skin. H2 reacts with every oxidizing element, the ground state energy level of the electron in a hydrogen atom is −13.6 eV, which is equivalent to an ultraviolet photon of roughly 91 nm wavelength. The energy levels of hydrogen can be calculated fairly accurately using the Bohr model of the atom, however, the atomic electron and proton are held together by electromagnetic force, while planets and celestial objects are held by gravity. The most complicated treatments allow for the effects of special relativity
19.
Oxygen
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Oxygen is a chemical element with symbol O and atomic number 8. It is a member of the group on the periodic table and is a highly reactive nonmetal. By mass, oxygen is the third-most abundant element in the universe, after hydrogen, at standard temperature and pressure, two atoms of the element bind to form dioxygen, a colorless and odorless diatomic gas with the formula O2. This is an important part of the atmosphere and diatomic oxygen gas constitutes 20. 8% of the Earths atmosphere, additionally, as oxides the element makes up almost half of the Earths crust. Most of the mass of living organisms is oxygen as a component of water, conversely, oxygen is continuously replenished by photosynthesis, which uses the energy of sunlight to produce oxygen from water and carbon dioxide. Oxygen is too reactive to remain a free element in air without being continuously replenished by the photosynthetic action of living organisms. Another form of oxygen, ozone, strongly absorbs ultraviolet UVB radiation, but ozone is a pollutant near the surface where it is a by-product of smog. At low earth orbit altitudes, sufficient atomic oxygen is present to cause corrosion of spacecraft, the name oxygen was coined in 1777 by Antoine Lavoisier, whose experiments with oxygen helped to discredit the then-popular phlogiston theory of combustion and corrosion. One of the first known experiments on the relationship between combustion and air was conducted by the 2nd century BCE Greek writer on mechanics, Philo of Byzantium. In his work Pneumatica, Philo observed that inverting a vessel over a burning candle, Philo incorrectly surmised that parts of the air in the vessel were converted into the classical element fire and thus were able to escape through pores in the glass. Many centuries later Leonardo da Vinci built on Philos work by observing that a portion of air is consumed during combustion and respiration, Oxygen was discovered by the Polish alchemist Sendivogius, who considered it the philosophers stone. In the late 17th century, Robert Boyle proved that air is necessary for combustion, English chemist John Mayow refined this work by showing that fire requires only a part of air that he called spiritus nitroaereus. From this he surmised that nitroaereus is consumed in both respiration and combustion, Mayow observed that antimony increased in weight when heated, and inferred that the nitroaereus must have combined with it. Accounts of these and other experiments and ideas were published in 1668 in his work Tractatus duo in the tract De respiratione. Robert Hooke, Ole Borch, Mikhail Lomonosov, and Pierre Bayen all produced oxygen in experiments in the 17th and the 18th century but none of them recognized it as a chemical element. This may have been in part due to the prevalence of the philosophy of combustion and corrosion called the phlogiston theory, which was then the favored explanation of those processes. Established in 1667 by the German alchemist J. J. Becher, one part, called phlogiston, was given off when the substance containing it was burned, while the dephlogisticated part was thought to be its true form, or calx. The fact that a substance like wood gains overall weight in burning was hidden by the buoyancy of the combustion products
20.
Acid
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An acid is a molecule or ion capable of donating a hydron, or, alternatively, capable of forming a covalent bond with an electron pair. The first category of acids is the donors or Brønsted acids. In the special case of solutions, proton donors form the hydronium ion H3O+ and are known as Arrhenius acids. Brønsted and Lowry generalized the Arrhenius theory to include non-aqueous solvents, acids form aqueous solutions with a sour taste, can turn blue litmus red, and react with bases and certain metals to form salts. The word acid is derived from the Latin acidus/acēre meaning sour, an aqueous solution of an acid has a pH less than 7 and is colloquially also referred to as acid, while the strict definition refers only to the solute. A lower pH means a higher acidity, and thus a higher concentration of hydrogen ions in the solution. Chemicals or substances having the property of an acid are said to be acidic, common aqueous acids include hydrochloric acid, acetic acid, sulfuric acid, and citric acid. As these examples show, acids can be solutions or pure substances, strong acids and some concentrated weak acids are corrosive, but there are exceptions such as carboranes and boric acid. The second category of acids are Lewis acids, which form a covalent bond with an electron pair, however, hydrogen chloride, acetic acid, and most other Brønsted-Lowry acids cannot form a covalent bond with an electron pair and are therefore not Lewis acids. Conversely, many Lewis acids are not Arrhenius or Brønsted-Lowry acids, in modern terminology, an acid is implicitly a Brønsted acid and not a Lewis acid, since chemists almost always refer to a Lewis acid explicitly as a Lewis acid. Modern definitions are concerned with the chemical reactions common to all acids. Most acids encountered in life are aqueous solutions, or can be dissolved in water, so the Arrhenius. The Brønsted-Lowry definition is the most widely used definition, unless otherwise specified, hydronium ions are acids according to all three definitions. Interestingly, although alcohols and amines can be Brønsted-Lowry acids, they can function as Lewis bases due to the lone pairs of electrons on their oxygen and nitrogen atoms. The Swedish chemist Svante Arrhenius attributed the properties of acidity to hydrogen ions or protons in 1884, an Arrhenius acid is a substance that, when added to water, increases the concentration of H+ ions in the water. Thus, an Arrhenius acid can also be described as a substance that increases the concentration of ions when added to water. Examples include molecular substances such as HCl and acetic acid, an Arrhenius base, on the other hand, is a substance which increases the concentration of hydroxide ions when dissolved in water. Thus, an Arrhenius acid could also be said to be one that decreases hydroxide concentration, in an acidic solution, the concentration of hydronium ions is greater than 10−7 moles per liter
21.
Water
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Water is a transparent and nearly colorless chemical substance that is the main constituent of Earths streams, lakes, and oceans, and the fluids of most living organisms. Its chemical formula is H2O, meaning that its molecule contains one oxygen, Water strictly refers to the liquid state of that substance, that prevails at standard ambient temperature and pressure, but it often refers also to its solid state or its gaseous state. It also occurs in nature as snow, glaciers, ice packs and icebergs, clouds, fog, dew, aquifers, Water covers 71% of the Earths surface. It is vital for all forms of life. Only 2. 5% of this water is freshwater, and 98. 8% of that water is in ice and groundwater. Less than 0. 3% of all freshwater is in rivers, lakes, and the atmosphere, a greater quantity of water is found in the earths interior. Water on Earth moves continually through the cycle of evaporation and transpiration, condensation, precipitation. Evaporation and transpiration contribute to the precipitation over land, large amounts of water are also chemically combined or adsorbed in hydrated minerals. Safe drinking water is essential to humans and other even though it provides no calories or organic nutrients. There is a correlation between access to safe water and gross domestic product per capita. However, some observers have estimated that by 2025 more than half of the population will be facing water-based vulnerability. A report, issued in November 2009, suggests that by 2030, in developing regions of the world. Water plays an important role in the world economy, approximately 70% of the freshwater used by humans goes to agriculture. Fishing in salt and fresh water bodies is a source of food for many parts of the world. Much of long-distance trade of commodities and manufactured products is transported by boats through seas, rivers, lakes, large quantities of water, ice, and steam are used for cooling and heating, in industry and homes. Water is an excellent solvent for a variety of chemical substances, as such it is widely used in industrial processes. Water is also central to many sports and other forms of entertainment, such as swimming, pleasure boating, boat racing, surfing, sport fishing, Water is a liquid at the temperatures and pressures that are most adequate for life. Specifically, at atmospheric pressure of 1 bar, water is a liquid between the temperatures of 273.15 K and 373.15 K
22.
Alcohol
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In chemistry, an alcohol is any organic compound in which the hydroxyl functional group is bound to a saturated carbon atom. The term alcohol originally referred to the alcohol ethanol, the predominant alcohol in alcoholic beverages. The suffix -ol in non-systematic names also typically indicates that the substance includes a functional group and, so. But many substances, particularly sugars contain hydroxyl functional groups without using the suffix, an important class of alcohols, of which methanol and ethanol are the simplest members is the saturated straight chain alcohols, the general formula for which is CnH2n+1OH. The word alcohol is from the Arabic kohl, a used as an eyeliner. Al- is the Arabic definite article, equivalent to the in English, alcohol was originally used for the very fine powder produced by the sublimation of the natural mineral stibnite to form antimony trisulfide Sb 2S3, hence the essence or spirit of this substance. It was used as an antiseptic, eyeliner, and cosmetic, the meaning of alcohol was extended to distilled substances in general, and then narrowed to ethanol, when spirits as a synonym for hard liquor. Bartholomew Traheron, in his 1543 translation of John of Vigo, Vigo wrote, the barbarous auctours use alcohol, or alcofoll, for moost fine poudre. The 1657 Lexicon Chymicum, by William Johnson glosses the word as antimonium sive stibium, by extension, the word came to refer to any fluid obtained by distillation, including alcohol of wine, the distilled essence of wine. Libavius in Alchymia refers to vini alcohol vel vinum alcalisatum, Johnson glosses alcohol vini as quando omnis superfluitas vini a vino separatur, ita ut accensum ardeat donec totum consumatur, nihilque fæcum aut phlegmatis in fundo remaneat. The words meaning became restricted to spirit of wine in the 18th century and was extended to the class of substances so-called as alcohols in modern chemistry after 1850, the term ethanol was invented 1892, based on combining the word ethane with ol the last part of alcohol. In the IUPAC system, in naming simple alcohols, the name of the alkane chain loses the terminal e and adds ol, e. g. as in methanol and ethanol. When necessary, the position of the group is indicated by a number between the alkane name and the ol, propan-1-ol for CH 3CH 2CH 2OH, propan-2-ol for CH 3CHCH3. If a higher priority group is present, then the prefix hydroxy is used, in other less formal contexts, an alcohol is often called with the name of the corresponding alkyl group followed by the word alcohol, e. g. methyl alcohol, ethyl alcohol. Propyl alcohol may be n-propyl alcohol or isopropyl alcohol, depending on whether the group is bonded to the end or middle carbon on the straight propane chain. As described under systematic naming, if another group on the molecule takes priority, Alcohols are then classified into primary, secondary, and tertiary, based upon the number of carbon atoms connected to the carbon atom that bears the hydroxyl functional group. The primary alcohols have general formulas RCH2OH, the simplest primary alcohol is methanol, for which R=H, and the next is ethanol, for which R=CH3, the methyl group. Secondary alcohols are those of the form RRCHOH, the simplest of which is 2-propanol, for the tertiary alcohols the general form is RRRCOH
23.
Experiment
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An experiment is a procedure carried out to support, refute, or validate a hypothesis. Experiments provide insight into cause-and-effect by demonstrating what outcome occurs when a particular factor is manipulated, experiments vary greatly in goal and scale, but always rely on repeatable procedure and logical analysis of the results. There also exists natural experimental studies, a child may carry out basic experiments to understand gravity, while teams of scientists may take years of systematic investigation to advance their understanding of a phenomenon. Experiments and other types of activities are very important to student learning in the science classroom. Experiments can raise test scores and help a student become more engaged and interested in the material they are learning, experiments can vary from personal and informal natural comparisons, to highly controlled. Uses of experiments vary considerably between the natural and human sciences, experiments typically include controls, which are designed to minimize the effects of variables other than the single independent variable. This increases the reliability of the results, often through a comparison between control measurements and the other measurements, scientific controls are a part of the scientific method. Ideally, all variables in an experiment are controlled and none are uncontrolled, in such an experiment, if all controls work as expected, it is possible to conclude that the experiment works as intended, and that results are due to the effect of the tested variable. In the scientific method, an experiment is a procedure that arbitrates between competing models or hypotheses. Researchers also use experimentation to test existing theories or new hypotheses to support or disprove them, an experiment usually tests a hypothesis, which is an expectation about how a particular process or phenomenon works. However, an experiment may also aim to answer a question, without a specific expectation about what the experiment reveals. If an experiment is conducted, the results usually either support or disprove the hypothesis. According to some philosophies of science, an experiment can never prove a hypothesis, on the other hand, an experiment that provides a counterexample can disprove a theory or hypothesis. An experiment must also control the possible confounding factors—any factors that would mar the accuracy or repeatability of the experiment or the ability to interpret the results, confounding is commonly eliminated through scientific controls and/or, in randomized experiments, through random assignment. In engineering and the sciences, experiments are a primary component of the scientific method. They are used to test theories and hypotheses about how physical processes work under particular conditions, typically, experiments in these fields focus on replication of identical procedures in hopes of producing identical results in each replication. In medicine and the sciences, the prevalence of experimental research varies widely across disciplines. In contrast to norms in the sciences, the focus is typically on the average treatment effect or another test statistic produced by the experiment
24.
Le Chatelier's principle
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In chemistry, Le Chateliers principle, also called Chateliers principle or The Equilibrium Law, can be used to predict the effect of a change in conditions on a chemical equilibrium. The principle is named after Henry Louis Le Chatelier and sometimes Karl Ferdinand Braun who discovered it independently, in other words, whenever a system in equilibrium is disturbed the system will adjust itself in such a way that the effect of the change will be nullified. This principle has a variety of names, depending upon the discipline using it and it is common to take Le Chateliers principle to be a more general observation, roughly stated, Any change in status quo prompts an opposing reaction in the responding system. In chemistry, the principle is used to manipulate the outcomes of reversible reactions, in economics, the principle has been generalized to help explain the price equilibrium of efficient economic systems. In simultaneous equilibrium systems, phenomena that are in apparent contradiction to Le Chateliers principle can occur, the duration of adjustment depends on the strength of the negative feedback to the initial shock. Where a shock initially induces positive feedback, the new equilibrium can be far from the old one, in some dynamic systems, the end-state cannot be determined from the shock. The principle has analogs throughout the physical world. Moreover, the response will generally be via the mechanism that most easily relieves that stress, changing the concentration of a chemical will shift the equilibrium to the side that would reduce that change in concentration. The chemical system will attempt to oppose the change affected to the original state of equilibrium. In turn, the rate of reaction, extent, and yield of products will be altered corresponding to the impact on the system and this can be illustrated by the equilibrium of carbon monoxide and hydrogen gas, reacting to form methanol. CO +2 H2 ⇌ CH3OH Suppose we were to increase the concentration of CO in the system, using Le Chateliers principle, we can predict that the amount of methanol will increase, decreasing the total change in CO. If we are to add a species to the overall reaction, likewise, the subtraction of a species would cause the reaction to fill the gap and favor the side where the species was reduced. This observation is supported by the collision theory, as the concentration of CO is increased, the frequency of successful collisions of that reactant would increase also, allowing for an increase in forward reaction, and generation of the product. Even if the product is not thermodynamically favored, the end-product can be obtained if it is continuously removed from the solution. When the reaction is exothermic, heat is included as a product, and, hence, whether increasing or decreasing the temperature would favor the forward or the reverse reaction can be determined by applying the same principle as with concentration changes. In exothermic reactions, increase in temperature decreases the equilibrium constant, K, whereas, in endothermic reactions, Le Chateliers principle applied to changes in concentration or pressure can be understood by having K have a constant value. The effect of temperature on equilibria, however, involves a change in the equilibrium constant, the dependence of K on temperature is determined by the sign of ΔH. The theoretical basis of this dependence is given by the Van t Hoff equation, the equilibrium concentrations of the products and reactants do not directly depend on the total pressure of the system but they do depend on the partial pressures of the products and reactants
25.
Universal indicator
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Although there are several commercially available universal pH indicators, most are a variation of a formula patented by Yamada in 1933. Details of this patent can be found in Chemical Abstracts, experiments with Yamadas universal indicator are also described in the Journal of Chemical Education. A universal indicator is composed of water, propan-1-ol, phenolphthalein sodium salt, sodium hydroxide, methyl red, bromothymol blue monosodium salt. Wide-range pH test papers with distinct colours for each pH from 1 to 14 are also available, colour matching charts are supplied with the specific test strips purchased. A universal indicator is collectively a mixture of indicators which show a change in a solution. A universal indicator can be in form or present in a form of a solution. Paper form, Is a strip of coloured paper which changes colour to red if the solution is acidic, the strip can be placed directly onto a surface of a wet substance or few drops of the solution can be dropped onto the universal indicator using dropping equipment. If the test solution is of a colour, it is preferable to use a paper universal indicator. Solution, The main components of a Universal indicator, in the form of a solution, are blue, methyl red, bromothymol blue. This mixture is important because each component loses or gains protons depending upon the acidity or basicity of the solution being tested and it is beneficial to use this type of a universal indicator in a colourless solution. This will increase the accuracy of indication
26.
Methyl red
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Acid Red 2, is an indicator dye that turns red in acidic solutions. It is an azo dye, and is a red crystalline powder. Methyl red is a pH indicator, it is red in pH under 4.4, yellow in pH over 6.2, murexide and methyl red are investigated as promising enhancers of sonochemical destruction of chlorinated hydrocarbon pollutants. Methyl red is classed by the IARC in group 3 - unclassified as to carcinogenic potential in humans, the MR test, the M portion of the four IMViC tests, is used to identify enteric bacteria based on their pattern of glucose metabolism. All enterics initially produce pyruvic acid from glucose metabolism, some enterics subsequently use the mixed acid pathway to metabolize pyruvic acid to other acids, such as lactic, acetic, and formic acids. These bacteria are called methyl-red positive and include Escherichia coli and Proteus vulgaris, other enterics subsequently use the butylene glycol pathway to metabolize pyruvic acid to neutral end products. These bacteria are called methyl-red-negative and include Serratia marcescens and Enterobacter aerogenes, an isolate is inoculated into a tube with a sterile transfer loop. The tube is incubated at 35 °C for 2–5 days, after incubation,2.5 ml of the medium are transferred to another tube. Five drops of the pH indicator methyl red is added to this tube, the tube is gently rolled between the palms to disperse the methyl red. Enterics that subsequently metabolize pyruvic acid to other acids lower the pH of the medium to 4.2, at this pH, methyl red turns red, a positive test. Enterics that subsequently metabolize pyruvic acid to neutral end products lower the pH of the medium to only 6.0, at this pH, methyl red is yellow, a negative test. Methyl Universal Indicator pH indicators Methyl yellow Methyl orange Methyl violet Microbiology, A Photographic Atlas for the Laboratory, Alexander, Street, nile Chemicals -- Methyl Red A site showing some extra information on methyl red
27.
Bromothymol blue
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Bromothymol blue is a pH indicator. It is mostly used in applications that require measuring substances that would have a relatively neutral pH, a common use is for measuring the presence of carbonic acid in a liquid. It is typically sold in form as the sodium salt of the acid indicator. Bromothymol blue acts as an acid in solution. It can thus be in protonated or deprotonated form, appearing yellow or blue and it is bright aquamarine by itself, and greenish-blue in a neutral solution. The deprotonation of the form results in a highly conjugated structure. An intermediate of the mechanism is responsible for the greenish color in neutral solution. The general carbon skeleton of bromothymol blue is common to many indicators including chlorophenol red, thymol blue, the presence of one moderate electron withdrawing group and two moderate donating groups are responsible for bromothymol blues active indication range from a pH of 6.0 to 7.6. While the conjugation is responsible for the length and nature of the color change range, Bromothymol blue is sparingly soluble in oil, but soluble in water, ether, and aqueous solutions of alkalis. It is less soluble in solvents such as benzene, toluene, and xylene. To prepare a solution for use as pH indicator, dissolve 0.10 g in 8.0 cm3 N/50 NaOH, to prepare a solution for use as indicator in volumetric work, dissolve 0.1 g in 100 cm3 of 50% ethanol. Bromothymol blue may be used for observing photosynthetic activities, or as a respiratory indicator, a common demonstration of BTBs pH indicator properties involves exhaling through a tube into a neutral solution of BTB. As carbon dioxide is absorbed from the breath into the solution, forming carbonic acid, thus, BTB is commonly used in science classes to demonstrate that the more that muscles are used, the greater the CO2 output. However, a recent study suggests that red is more useful in determining activity due to the bright yellow ring form in the zone of enzyme activity. It may also be used in the laboratory as a biological slide stain, at this point, it is already blue, and a few drops are used on a water slide. The cover slip is placed on top of the water droplet and it is sometimes used to define cell walls or nuclei under the microscope. Bromothymol is used in obstetrics for detecting premature rupture of membranes, amniotic fluid typically has a pH >7.2, bromothymol will therefore turn blue when brought in contact with fluid leaking from the amnion. As vaginal pH normally is acidic, the color indicates the presence of amniotic fluid
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Thymol blue
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Thymol blue is a brownish-green or reddish-brown crystalline powder that is used as a pH indicator. It is insoluble in water but soluble in alcohol and dilute alkali solutions and it transitions from red to yellow at pH1. 2–2.8 and from yellow to blue at pH8. 0–9.6. It is usually a component of Universal indicator, thymol blue has different structures at different pH. Its toxicological properties have not been fully investigated
29.
Ion
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An ion is an atom or a molecule in which the total number of electrons is not equal to the total number of protons, giving the atom or molecule a net positive or negative electrical charge. Ions can be created, by chemical or physical means. In chemical terms, if an atom loses one or more electrons. If an atom gains electrons, it has a net charge and is known as an anion. Ions consisting of only a single atom are atomic or monatomic ions, because of their electric charges, cations and anions attract each other and readily form ionic compounds, such as salts. In the case of ionization of a medium, such as a gas, which are known as ion pairs are created by ion impact, and each pair consists of a free electron. The word ion comes from the Greek word ἰόν, ion, going and this term was introduced by English physicist and chemist Michael Faraday in 1834 for the then-unknown species that goes from one electrode to the other through an aqueous medium. Faraday also introduced the words anion for a charged ion. In Faradays nomenclature, cations were named because they were attracted to the cathode in a galvanic device, arrhenius explanation was that in forming a solution, the salt dissociates into Faradays ions. Arrhenius proposed that ions formed even in the absence of an electric current, ions in their gas-like state are highly reactive, and do not occur in large amounts on Earth, except in flames, lightning, electrical sparks, and other plasmas. These gas-like ions rapidly interact with ions of charge to give neutral molecules or ionic salts. These stabilized species are commonly found in the environment at low temperatures. A common example is the present in seawater, which are derived from the dissolved salts. Electrons, due to their mass and thus larger space-filling properties as matter waves, determine the size of atoms. Thus, anions are larger than the parent molecule or atom, as the excess electron repel each other, as such, in general, cations are smaller than the corresponding parent atom or molecule due to the smaller size of its electron cloud. One particular cation contains no electrons, and thus consists of a single proton - very much smaller than the parent hydrogen atom. Since the electric charge on a proton is equal in magnitude to the charge on an electron, an anion, from the Greek word ἄνω, meaning up, is an ion with more electrons than protons, giving it a net negative charge. A cation, from the Greek word κατά, meaning down, is an ion with fewer electrons than protons, there are additional names used for ions with multiple charges
30.
Fuchsia (color)
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Fuchsia is a vivid purplish red color, named after the color of the flower of the fuchsia plant, which took its name from the 16th century German botanist Leonhart Fuchs. The color fuchsia was first introduced as the color of a new aniline dye called fuchsine, patented in 1859 by the French chemist François-Emmanuel Verguin. The dye was renamed later in the same year, to celebrate a victory of the French army at the Battle of Magenta on June 4,1859. In color printing and design, there are variations between magenta and fuchsia. Fuchsia is usually a more color, whereas magenta is more reddish. Fuchsia flowers themselves contain a variety of purples. The first recorded use of fuchsia as a name in English was in 1892. The first synthetic dye the color of fuchsia, called fuchsine, was patented in 1859 by François-Emmanuel Verguin and it was later renamed magenta, and became highly popular under that name. The name fuchsia is used on the HTML web color list for this color and they are both composed the same way, by combining an equal amount of blue and red light at full brightness, as shown in the image on the left. Displayed at right is the pale tint of fuchsia. The first recorded use of fuchsia as a color name in English was in 2014. At right is displayed the color French fuchsia, which is the tone of fuchsia called fuchsia in a color list popular in France, fashion fuchsia is a color used in fashion when a slightly less saturated color than shocking pink is desired. It also goes by the name Hollywood cerise, Fuchsia rose is the color that was chosen as the 2001 Pantone color of the year by Pantone. The source of color is the Pantone Textile Paper eXtended color list. Although red-purple is a seldom used color name in English, in Spanish it is regarded one of the tones of purple. The color fuchsia purple is displayed at right, the source of this color is the Pantone Textile Paper eXtended color list, color #18-2436 TPX—Fuchsia Purple. Deep fuchsia is the color that is called fuchsia in the List of Crayola crayon colors, displayed at right is the color fandango. The first recorded use of fandango as a name in English was in 1925
31.
Calcium hydroxide
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Calcium hydroxide, traditionally called slaked lime, is an inorganic compound with the chemical formula Ca2. It is a crystal or white powder and is obtained when calcium oxide is mixed. It has many names including hydrated lime, caustic lime, builders lime, slack lime, cal, Calcium hydroxide is used in many applications, including food preparation. Limewater is the name for a saturated solution of calcium hydroxide. Calcium hydroxide is insoluble in water, with a solubility product Ksp of 5.5 × 10−6.4. Calcium hydroxide solutions can cause chemical burns, at high pH value, its solubility drastically decreases. This behavior is relevant to cement pastes, Ca2 → CaO + H2O Calcium hydroxide adopts a polymeric structure, as do all metal hydroxides. The structure is identical to that of Mg2, i. e. the cadmium iodide motif, strong hydrogen bonds exist between the layers. Calcium hydroxide is produced commercially by treating lime with water, CaO + H2O → Ca2 In the laboratory it can be prepared by mixing solutions of calcium chloride. The mineral form, portlandite, is rare but can be found in some volcanic, plutonic. It has also known to arise in burning coal dumps. CaOH has been detected in the atmosphere of S-type stars, one significant application of calcium hydroxide is as a flocculant, in water and sewage treatment. It forms a fluffy charged solid that aids in the removal of particles from water. This application is enabled by the low cost and low toxicity of calcium hydroxide and this conversion is part of the causticizing step in the Kraft process for making pulp. In Spanish, calcium hydroxide is called cal, corn cooked with cal becomes hominy, which significantly increases the bioavailability of niacin, and it is also considered tastier and easier to digest. In chewing coca leaves, calcium hydroxide is usually chewed alongside to keep the alkaloid stimulants chemically available for absorption by the body, similarly, Native Americans traditionally chewed tobacco leaves with calcium hydroxide derived from burnt mollusk shells to enhance the effects. It has also used by some indigenous American tribes as an ingredient in yopo. Calcium hydroxide is added to a bundle of areca nut
32.
Portland cement
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Portland cement is the most common type of cement in general use around the world, used as a basic ingredient of concrete, mortar, stucco, and most non-speciality grout. It was developed from other types of lime in England in the mid 19th century. It is a fine powder produced by heating materials in a kiln to form what is called clinker, grinding the clinker, and adding small amounts of other materials. Several types of Portland cement are available, with the most common being called ordinary Portland cement which is grey in color, Portland cement is caustic, so it can cause chemical burns. The powder can cause irritation or, with exposure, lung cancer and can contain some hazardous components such as crystalline silica. Concrete produced from Portland cement is one of the most versatile construction materials available in the world, Portland cement was developed from natural cements made in Britain beginning in the middle of the 18th century. Its name is derived from its similarity to Portland stone, a type of building stone quarried on the Isle of Portland in Dorset, England. In the late 18th century, Roman cement was developed and patented in 1796 by James Parker, Roman cement quickly became popular, in 1811 James Frost produced a cement he called British cement. James Frost is reported to have erected a manufactory for making of an artificial cement in 1826, in 1843, Aspdins son William improved their cement, which was initially called Patent Portland cement, although he had no patent. In 1818, French engineer Louis Vicat invented a hydraulic lime considered the principal forerunner of Portland cement. Edgar Dobbs of Southwark patented a cement of this kind in 1811, Portland cement was used by Joseph Aspdin in his cement patent in 1824 because of the cements resemblance to Portland stone. The name Portland cement is also recorded in a directory published in 1823 being associated with a William Lockwood, a Dave Stewart, however, Aspdins cement was nothing like modern Portland cement but was a first step in the development of modern Portland cement, called a proto-Portland cement. William Aspdin had left his fathers company and in his cement manufacturing apparently accidentally produced calcium silicates in the 1840s, in 1848, William Aspdin further improved his cement, in 1853, he moved to Germany, where he was involved in cement making. William Aspdin made what could be called meso-Portland cement, isaac Charles Johnson further refined the production of meso-Portland cement and claimed to be the real father of Portland cement. John Grant of the Metropolitan Board of Works in 1859 set out requirements for cement to be used in the London sewer project and this became a specification for Portland cement. The Hoffman endless kiln which gave control over combustion was tested in 1860. This cement was made at the Portland Cementfabrik Stern at Stettin and it is thought that the first modern Portland cement was made there. The Association of German Cement Manufacturers issued a standard on Portland cement in 1878, by the early 20th century American-made Portland cement had displaced most of the imported Portland cement
33.
Barbie
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Barbie is a fashion doll manufactured by the American toy company Mattel, Inc. and launched in March 1959. American businesswoman Ruth Handler is credited with the creation of the using a German doll called Bild Lilli as her inspiration. Barbie is the figurehead of a brand of Mattel dolls and accessories, including family members. Mattel has sold over a billion Barbie dolls, making it the company’s largest and most profitable line, however, sales have declined sharply since 2014. The doll transformed the toy business in affluent communities worldwide by becoming a vehicle for the sale of related merchandise, Ruth Handler watched her daughter Barbara play with paper dolls, and noticed that she often enjoyed giving them adult roles. At the time, most childrens toy dolls were representations of infants, realizing that there could be a gap in the market, Handler suggested the idea of an adult-bodied doll to her husband Elliot, a co-founder of the Mattel toy company. He was unenthusiastic about the idea, as were Mattels directors, during a trip to Europe in 1956 with her children Barbara and Kenneth, Ruth Handler came across a German toy doll called Bild Lilli. The adult-figured doll was exactly what Handler had in mind, so she purchased three of them and she gave one to her daughter and took the others back to Mattel. The Lilli doll was based on a character appearing in a comic strip drawn by Reinhard Beuthin for the newspaper Bild. Lilli was a bombshell, a working girl who knew what she wanted and was not above using men to get it. The Lilli doll was first sold in Germany in 1955, and although it was sold to adults. Upon her return to the United States, Handler redesigned the doll, the doll made its debut at the American International Toy Fair in New York on March 9,1959. This date is used as Barbies official birthday. The first Barbie doll wore a black and white zebra striped swimsuit and signature topknot ponytail, the doll was marketed as a Teen-age Fashion Model, with her clothes created by Mattel fashion designer Charlotte Johnson. The first Barbie dolls were manufactured in Japan, with their clothes hand-stitched by Japanese homeworkers, around 350,000 Barbie dolls were sold during the first year of production. Louis Marx and Company sued Mattel in March 1961, after licensing Lilli, they claimed that Mattel had “infringed on Greiner & Haussers patent for Bild-Lilli’s hip joint, and also claimed that Barbie was a direct take-off and copy of Bild-Lilli. The company additionally claimed that Mattel falsely and misleadingly represented itself as having originated the design, Mattel counter-claimed and the case was settled out of court in 1963. In 1964, Mattel bought Greiner & Haussers copyright and patent rights for the Bild-Lilli doll for $21,600
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