The Philadelphia Zoo, located in the Centennial District of Philadelphia on the west bank of the Schuylkill River, is the first true zoo in the United States. It was chartered by the Commonwealth of Pennsylvania on March 21, 1859, but its opening was delayed by the Civil War until July 1, 1874. The zoo opened with 1,000 animals and an admission price of 25 cents. For a brief time, the zoo also housed animals brought to U.S. from safaris by the Smithsonian Institution, which had not yet built its National Zoo.

West Philadelphia, nicknamed West Philly, is a section of the city of Philadelphia. Although there are no officially defined boundaries, it is generally considered to reach from the western shore of the Schuylkill River, to City Avenue to the northwest, Cobbs Creek to the southwest, and the SEPTA Media/Wawa Line to the south. An alternate definition includes all city land west of the Schuylkill; this would also include Southwest Philadelphia and its neighborhoods. The eastern side of West Philadelphia is also known as University City.