Philip Humber of the Chicago White Sox pitched a perfect game against the Seattle Mariners by retiring all 27 batters he faced on April 21, 2012, as the White Sox defeated the Mariners 4–0. It was the 21st perfect game in Major League Baseball (MLB) history and the third by a member of the White Sox, and remains the earliest calendar date for a perfect game in MLB history. It was Humber's first career complete game, although he had come close to achieving no-hitters on several occasions at several levels of organized baseball. The game was played in Seattle and broadcast regionally by Fox Sports in the two teams' metropolitan areas.

Philip Gregory Humber is an American former professional baseball pitcher. He pitched for the New York Mets, Minnesota Twins, Kansas City Royals, Chicago White Sox, and Houston Astros in seven seasons in Major League Baseball (MLB). Although he debuted in the major leagues in 2006 and had worked mostly as a starter in the minor leagues, he did not become a regular MLB starter until 2011.