Philosophical skepticism is a family of philosophical views that question the possibility of knowledge. It differs from other forms of skepticism in that it even rejects very plausible knowledge claims that belong to basic common sense. Philosophical skeptics are often classified into two general categories: Those who deny all possibility of knowledge, and those who advocate for the suspension of judgment due to the inadequacy of evidence. This distinction is modeled after the differences between the Academic skeptics and the Pyrrhonian skeptics in ancient Greek philosophy. In the latter sense, skepticism is understood as a way of life that helps the practitioner achieve inner peace. Some types of philosophical skepticism reject all forms of knowledge while others limit this rejection to certain fields, for example, knowledge about moral doctrines or about the external world. Some theorists criticize philosophical skepticism based on the claim that it is a self-refuting idea since its proponents seem to claim to know that there is no knowledge. Other objections focus on its implausibility and distance from regular life.

Originally, fallibilism is the philosophical principle that propositions can be accepted even though they cannot be conclusively proven or justified, or that neither knowledge nor belief is certain. The term was coined in the late nineteenth century by the American philosopher Charles Sanders Peirce, as a response to foundationalism. Theorists, following Austrian-British philosopher Karl Popper, may also refer to fallibilism as the notion that knowledge might turn out to be false. Furthermore, fallibilism is said to imply corrigibilism, the principle that propositions are open to revision. Fallibilism is often juxtaposed with infallibilism.