Phraates IV was King of Kings of the Parthian Empire from 37 to 2 BC. He was the son and successor of Orodes II, and was given the throne after the death of his brother Pacorus I. Phraates IV soon murdered all his brothers, and also possibly his father. His actions alienated the Armenians and also some of his nobles, including the distinguished Monaeses, who fled to the Roman triumvir Mark Antony, but shortly returned and reconciled with Phraates IV.

The Parthian Empire, also known as the Arsacid Empire, was a major Iranian political and cultural power centered in ancient Iran from 247 BC to 224 AD. Its latter name comes from its founder, Arsaces I, who led the Parni tribe in conquering the region of Parthia in Iran's northeast, then a satrapy (province) under Andragoras, who was rebelling against the Seleucid Empire. Mithridates I greatly expanded the empire by seizing Media and Mesopotamia from the Seleucids. At its height, the Parthian Empire stretched from the northern reaches of the Euphrates, in what is now central-eastern Turkey, to present-day Afghanistan and western Pakistan. The empire, located on the Silk Road trade route between the Roman Empire in the Mediterranean Basin and the Han dynasty of China, became a center of trade and commerce.