Pickens County is located in the northwest part of the U.S. state of South Carolina. As of the 2020 census, its population was 131,404. Its county seat is Pickens. The county was created in 1826. It is part of the Greenville-Anderson-Greer, SC Metropolitan Statistical Area.

Pickens, formerly called Pickens Courthouse, is a city in and the county seat of Pickens County, South Carolina, United States. The population was 3,126 at the 2010 census. Pickens changed its classification from a town to a city in 1998, but it was not reported to the Census Bureau until 2001. It was named after Andrew Pickens (1739–1817), an American revolutionary soldier and US Congressman for South Carolina.