Pickens County is located in the northwest part of the U.S. state of South Carolina. As of the 2020 census, its population was 131,404. Its county seat is Pickens. The county was created in 1826. It is part of the Greenville-Anderson-Greer, SC Metropolitan Statistical Area.
Pickens County Courthouse
Fort Hill, photographed in 1887, was the home of Thomas Green Clemson and his wife Anna Maria Calhoun, who inherited it from her mother. He carried out Anna Maria's wish to found an agricultural college here but was credited as founder.