Pickensville is a rural town in Pickens County, Alabama, United States. At the 2010 census the population was 608, down from 662 in 2000. It was initially incorporated in 1839 and briefly served before that as the first county seat of Pickens County. Carrollton was designated as the seat in the early 1830s.

Pickens County is a county located on the west central border of the U.S. state of Alabama. As of the 2020 census, the population was 19,123. Its county seat is Carrollton, located in the center of the county. It is a prohibition, or dry county, although the communities of Carrollton and Aliceville voted to become wet in 2011 and 2012, respectively.