Pickup on South Street is a 1953 Cold War spy-themed film noir written and directed by Samuel Fuller, and released by 20th Century-Fox. In 2018, Pickup on South Street was selected for preservation in the United States National Film Registry as being "culturally, historically, or aesthetically significant." The film stars Richard Widmark, Jean Peters, and Thelma Ritter. It was screened at the Venice Film Festival in 1953.

Samuel Michael "Sam" Fuller was an American film director, screenwriter, novelist, journalist, actor, and World War II veteran known for directing low-budget genre movies with controversial themes, often made outside the conventional studio system. Fuller wrote his first screenplay for Hats Off in 1936, and made his directorial debut with the Western I Shot Jesse James (1949). He would continue to direct several other Westerns and war thrillers throughout the 1950s.