The Pico family is a prominent Californio family of Southern California. Members of the family held extensive rancho grants and numerous important positions, including Governor of Alta California, signer of the Constitution of California, and California State Senator, among numerous others. Numerous locations are named after the family across California.

Rancho Simi, also known as Rancho San José de Nuestra Señora de Altagracia y Simí, was a 113,009-acre (457 km2) Spanish land grant in what is now eastern Ventura and western Los Angeles counties granted in 1795 to Santiago Pico, founder of the Pico family of California. After Santiago Pico's death in 1815, the Rancho was regranted to Santiago's sons Javier Pico and his two brothers, Patricio Pico and Miguel Pico by Diego de Borica. The name derives from Shimiji, the name of a Chumash village in the Simi Valley for thousands of years before the Spanish arrival.