Piedmont is a census-designated place (CDP) along the Saluda River in Anderson and Greenville counties in the U.S. state of South Carolina. The population was 5,411 at the 2020 census.

The Saluda River is a principal tributary of the Congaree River, about 200 mi (320 km) long, in northern and western South Carolina in the United States. Via the Congaree River, it is part of the watershed of the Santee River, which flows to the Atlantic Ocean.