Pierce City, formerly Peirce City, is a city in southwest Lawrence and northwest Barry counties, in southwest Missouri, United States. The population was 1,292 at the 2010 census. In 2010, the town annexed property along Route 97 into Barry County to a point just north of U.S. Route 60. It was estimated to be 1,309 by the City of Pierce City as of July 1, 2019.

Lawrence County is located in the southwest portion of the U.S. state of Missouri, in the area of the Ozarks. As of the 2020 census, the population was 38,001. Its county seat is Mount Vernon. The county was organized in 1845 and named for James Lawrence, a naval officer from the War of 1812 known for his battle cry, "Don't give up the ship!"