Piero Strozzi was an Italian military leader. He was a member of the rich Florentine family of the Strozzi.

The House of Strozzi is the name of an ancient Florentine family, who like their great rivals the Medici family, began in banking before moving into politics. Until its exile from Florence in 1434, the Strozzi family was by far the richest in the city, and was rivaled only by the Medici family, who ultimately took control of the government and ruined the Strozzi both financially and politically. This political and financial competition was the origin of the Strozzi-Medici rivalry. Later, while the Medici ruled Florence, the Strozzi family ruled Siena, which Florence attacked, causing great animosity between the two families. Soon afterward, the Strozzi married into the Medici family, essentially giving the Medici superiority.