Pierson Olin Prioleau [PEER-sun PRAY-low] is a former American football safety. He was selected by the San Francisco 49ers in the fourth round of the 1999 NFL Draft. He played college football at Virginia Tech and is currently on the coaching staff. He received a degree from Virginia Tech in interdisciplinary studies, graduating on May 14, 2011. Pierson served as the director of player development - defense under Justin Fuente at Virginia Tech from 2019 to 2021. Upon the hiring of Brent Pry as the new head coach for the Hokies, Pierson was promoted to an on-field position as the safeties coach, replacing fellow Hokie Justin Hamilton.

The 1999 NFL draft was the procedure by which National Football League teams selected amateur college football players. It is officially known as the NFL Annual Player Selection Meeting. The draft was held April 17–18, 1999, at the Theater at Madison Square Garden in New York City, New York. The league also held a supplemental draft after the regular draft and before the regular season.