Pike County is a county located in the U.S. state of Arkansas. As of the 2020 census, the population was 10,171. The county seat is Murfreesboro. Pike County is Arkansas's 25th county, formed on November 1, 1833, and named for Lieutenant Zebulon Pike, the explorer for whom Pikes Peak is named. It is an alcohol prohibition or dry county.

Zebulon Montgomery Pike was an American brigadier general and explorer for whom Pikes Peak in Colorado is named. As a U.S. Army officer he led two expeditions through the Louisiana Purchase territory, first in 1805–1806 to reconnoiter the upper northern reaches of the Mississippi River, and then in 1806–1807 to explore the southwest to the fringes of the northern Spanish-colonial settlements of New Mexico and Texas. Pike's expeditions coincided with other Jeffersonian expeditions, including the Lewis and Clark Expedition and the Red River Expedition in 1806.