Pike County is a county in the southwest portion of the U.S. state of Indiana. As of the 2020 United States census, the population was 12,250. The county seat is Petersburg. It contains the geographic point representing median center of US population in 2010.

Southwestern Indiana is an 11-county region of southern Indiana, United States located at the southernmost and westernmost part of the state. As of the 2010 census, the region's combined population is 474,251. Evansville, Indiana's third-largest city, is the primary hub for the region, as well as the primary regional hub for a tri-state area that includes Kentucky and Illinois. Other regional hubs include Jasper, Vincennes, and Washington. Although part of a Midwestern state, this region's culture and language, like much of the rest of Southern Indiana, is aligned more with that of the Upland South rather than the Midwest.