The Pillsbury A-Mill is a former flour mill located on the east bank of the Mississippi River in Minneapolis, Minnesota. It was the world's largest flour mill for 40 years. Completed in 1881, it was owned by the Pillsbury Company and operated two of the most powerful direct-drive waterwheels ever built, each capable of generating 1,200 horsepower . In 1901 one of the turbines was replaced with a 2,500 horsepower one. Both the mill and its headrace tunnel are contributing resources to the St. Anthony Falls Historic District, which is on the National Register of Historic Places. The mill is also independently on the NRHP. The mill was named a National Historic Landmark in 1966 and has since been converted into the A-Mill Artist Lofts.

Charles Alfred Pillsbury was an American businessman, flour industrialist, and politician. He was a co-founder of the Pillsbury Company.