The Pittsburgh railway strike occurred in Pittsburgh, Pennsylvania as part of the Great Railroad Strike of 1877. It was one of many incidents of strikes, labor unrest and violence in cities across the United States, including several in Pennsylvania. Other cities dealing with similar unrest included Philadelphia, Reading, Shamokin and Scranton. The incidents followed repeated reductions in wages and sometimes increases in workload by railroad companies, during a period of economic recession following the Panic of 1873.

The Panic of 1873 was a financial crisis that triggered an economic depression in Europe and North America that lasted from 1873 to 1877 or 1879 in France and in Britain. In Britain, the Panic started two decades of stagnation known as the "Long Depression" that weakened the country's economic leadership. In the United States, the Panic was known as the "Great Depression" until the events of 1929 and the early 1930s set a new standard.