The Plan of San Luis Potosí is a key political document of the Mexican Revolution, written by presidential candidate Francisco I. Madero following his escape from jail. He had challenged President Porfirio Díaz in the 1910 presidential elections, when Díaz was 80 years old, and garnered a broadbased following. Díaz jailed him when it became clear Madero might win. Madero escaped and drafted the plan to explain why armed rebellion against Díaz was now the only way to remove him from office. It was published on 5 October 1910. It called for nullifying the fraudulent 1910 election of Porfirio Díaz, proclaimed Madero as provisional president, and called on the Mexican people to revolt on 20 November 1910.

The Mexican Revolution was an extended sequence of armed regional conflicts in Mexico from 20 November 1910 to 1 December 1920. It has been called "the defining event of modern Mexican history" and resulted in the destruction of the Federal Army, its replacement by a revolutionary army, and the transformation of Mexican culture and government. The northern Constitutionalist faction prevailed on the battlefield and drafted the present-day Constitution of Mexico, which aimed to create a strong central government. Revolutionary generals held power from 1920 to 1940. The revolutionary conflict was primarily a civil war, but foreign powers, having important economic and strategic interests in Mexico, figured in the outcome of Mexico's power struggles; the U.S. involvement was particularly high. The conflict led to the deaths of around one million people, mostly noncombatants.