"Play the Guitar" is a song by American hip hop recording artist B.o.B, featuring fellow American rapper André 3000. Produced by Salaam Remi, it is a guitar driven hip hop song that samples "Bo Diddley" as performed by Bo Diddley as well as "Fancy" as performed by Drake, Swizz Beatz and T.I. It was recorded for his second studio album, Strange Clouds (2012), however failed to make the final cut.

Bobby Ray Simmons Jr., known professionally as B.o.B, is an American rapper, singer, and record producer. Raised in Decatur, Georgia, Simmons signed with producer Jim Jonsin through his Rebel Rock Entertainment label in 2006. Two years later, he signed a joint venture recording contract with fellow Georgia rapper T.I.'s Grand Hustle Records, an imprint of Atlantic Records. Following his major-label deal, Simmons quickly achieved commercial success when his 2009 debut single, "Nothin' on You", peaked the US Billboard Hot 100 chart and received three nominations—Record of the Year, Best Rap Song, and Best Rap/Sung Collaboration—at the 53rd Grammy Awards.