Plymouth Friary railway station was the London and South Western Railway (LSWR) terminus in Plymouth, Devon, England.

The London and South Western Railway was a railway company in England from 1838 to 1922. Originating as the London and Southampton Railway, its network extended to Dorchester and Weymouth, to Salisbury, Exeter and Plymouth, and to Padstow, Ilfracombe and Bude. It developed a network of routes in Hampshire, Surrey and Berkshire, including Portsmouth and Reading.