Polita Grau was the First Lady of Cuba, a Cuban political prisoner, and the "godmother" of Operation Peter Pan, also known as Operación Pedro Pan, a program to help children leave Cuba. Operation Peter Pan involved the Roman Catholic Church and Monsignor Bryan O. Walsh from 1960 to 1962, which were involved in encouraging Cuban parents to send their children to live with U.S families to rescue them from Communism.

First Lady of Cuba is de facto title of the wife of the President of the Republic of Cuba. The current first lady of Cuba is Lis Cuesta Peraza, the second wife of President Miguel Díaz-Canel, who is also the First Secretary of the Communist Party of Cuba, the most senior position in the Cuban government. She is the first presidential wife to be referred to as "first lady" by Cuban state media since the 1960s.