Between 1947 and 1977, General Electric polluted the Hudson River by discharging polychlorinated biphenyls (PCBs) causing a range of harmful effects to wildlife and people who eat fish from the river. Other kinds of pollution, including mercury contamination and cities discharging untreated sewage, have also caused problems in the river.

The Toxic Substances Control Act (TSCA) is a United States law, passed by the 94th United States Congress in 1976 and administered by the United States Environmental Protection Agency (EPA), that regulates chemicals not regulated by other U.S. federal statutes, including chemicals already in commerce and the introduction of new chemicals. When the TSCA was put into place, all existing chemicals were considered to be safe for use and subsequently grandfathered in. Its three main objectives are to assess and regulate new commercial chemicals before they enter the market, to regulate chemicals already existing in 1976 that posed an "unreasonable risk of injury to health or the environment", as for example PCBs, lead, mercury and radon, and to regulate these chemicals' distribution and use.